Nuclear Localization and Dynamic Properties of the Marek's Disease Virus Oncogene Products Meq and Meq/vIL8

Abstract

Marek's disease virus (MDV) is an avian herpesvirus that causes T-cell lymphomas and immune suppres

Genome-Wide Screen of Three Herpesviruses for Protein Subcellular Localization and Alteration of PML Nuclear Bodies

“…UL3 and UL30 have little sequence similarity and vary considerably in their contribution to CMV infection in fibroblasts; UL3 is classified a non-essential gene, while deletion of UL30 caused a severe defect in viral replication [46]. The Meq protein from the avian herpesvirus MDV has been reported to associate with Cajal bodies [7], however, to our knowledge, CMV UL3 and UL30 are the first human herpesvirus proteins reported to associate with or disrupt these structures. Although the functions of Cajal bodies are not completely clear, they are strongly associated with transcription and the maturation of ribonuclear particles and only form when these processes are active [49].…”

Avian Immunosuppressive Diseases and Immunoevasion

“…This suggests that vIL-8 affects virus replication rather than tumorigenesis. The possibility of immunomodulatory functions for vIL-8 cannot be eliminated, but the discovery that it can also be expressed as a fusion protein with the MDV oncoprotein Meq presents the likelihood of a more complicated situation [192].…”

Avian Immunosuppressive Diseases and Immune Evasion

“…This suggests that vIL-8 affects virus replication rather than tumorigenesis. The possibility of immunomodulatory functions for vIL-8 cannot be eliminated but the discovery that it can also be expressed as a fusion protein with the MDV oncoprotein Meq presents the likelihood of a more complicated situation (Anobile et al, 2006).…”