Nuclear imaging of molecular processes in cancer

Rosales, Rafael T. M. de; Årstad, Erik; Blower, Philip J.

doi:10.1007/s11523-009-0120-2

Cited by 13 publications

(4 citation statements)

References 116 publications

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“…Since the choice of chelator and radiometal influences the binding potential and biological potency [9], there is the possibility of modifying the excretion route, the biological activity, and lack of immunogenicity. Also, for imaging and therapy purposes, rapid clearance from nontarget tissues resulting in good tumour-to-background ratios is preferable [9,11,12].…”

Section: Development Of Peptides For Receptor Targetingmentioning

confidence: 99%

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Rationale for the use of radiolabelled peptides in diagnosis and therapy

Koopmans

Glaudemans

2012

Eur J Nucl Med Mol Imaging

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Nuclear medicine techniques are becoming more important in imaging oncological and infectious diseases. For metabolic imaging of these diseases, antibody and peptide imaging are currently used. In recent years peptide imaging has become important, therefore the rationale for the use of peptide imaging is described in this article. Criteria for a successful peptide tracer are a high target specificity, a high binding affinity, a long metabolic stability and a high target-to-background ratio. Tracer internalization is also beneficial. For oncological imaging, many tracers are available, most originating from regulatory peptides, but penetrating peptides are also being developed. Peptides for imaging inflammatory and infectious diseases include regulatory peptides, antimicrobial peptides and others. In conclusion, for the imaging of oncological, imflammatory and infectious diseases, many promising peptides are being developed. The ideal peptide probe is characterized by rapid and specific target localization and binding with a high tumour-to-background ratio.

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Section: Development Of Peptides For Receptor Targetingmentioning

confidence: 99%

“…In tumour tissues, the most important receptor subtypes are CCK1 and CCK2 [21,22]. In colonic, gastric and brain cancers, CCK and gastrin may act as growth factors [12]. Specifically in medullary thyroid cancer high CCK-2 receptor expression has been demonstrated in cell membranes.…”

Section: Cholecystokinin Analoguesmentioning

confidence: 99%

Rationale for the use of radiolabelled peptides in diagnosis and therapy

Koopmans

Glaudemans

2012

Eur J Nucl Med Mol Imaging

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“…This includes bioluminescent reporters, activatable probes, nanoparticles, quantum dots, radionuclide probes, metal chelate probes, and microbubbles [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25]. This review will focus on the current status and use of these targeted molecular probes, including dual labeled probes.…”

Section: Scope Of the Reviewmentioning

confidence: 99%

Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging

Joshi

Wang

2010

Cancers

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Cancer is one of the major causes of mortality and morbidity in our health care system. Molecular imaging is an emerging methodology for the early detection of cancer, and the development of exogenous molecular probes that can be labeled for multi-modality imaging is critical to this process. Today, molecular imaging is at crossroad, and new targeted imaging agents are expected to broadly expand our ability to detect pre-malignant lesions. This integrated imaging strategy will permit clinicians to not only localize lesions within the body, but also to visualize the expression and activity of specific molecules. This information is expected to have a major impact on diagnosis, therapy, drug development and understanding of basic cancer biology. At this time, a number of molecular probes have been developed by conjugating various labels to affinity ligands for targeting in different imaging modalities. This review will describe the current status of exogenous molecular probes for optical, nuclear and MRI imaging platforms. Furthermore, we will also shed light on how these techniques can be used synergistically in multi-modal platforms and how these techniques are being employed in current research.

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“…A recent review of nuclear imaging of cancer provides more in depth discussion of clinical aspects and compounds at a more advanced stage of development. 3…”

Section: Introductionmentioning

confidence: 99%

The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

Donnelly

2011

Dalton Trans.

105

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There are several isotopes of copper and rhenium that are of interest in the development of new molecular imaging or radiotherapeutic agents. This perspective article highlights the role of coordination chemistry in the design of copper and rhenium radiopharmaceuticals engineered to selectively target tissue of interest such as cancer cells or pathological features associated with Alzheimer's disease. The coordination chemistry of copper bis(thiosemicarbazone) derivatives and copper macrocyclic complexes is discussed in terms of their potential application as targeted positron emission tomography tracers for non-invasive diagnostic imaging. A range of rhenium complexes with different ligands with rhenium in different oxidation states are introduced and their potential to be translated to new radiotherapeutic agents discussed.

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Nuclear imaging of molecular processes in cancer

Cited by 13 publications

References 116 publications

Rationale for the use of radiolabelled peptides in diagnosis and therapy

Rationale for the use of radiolabelled peptides in diagnosis and therapy

Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging

The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

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