Nuclear IL-33 Plays an Important Role in EGFR-Mediated Keratinocyte Migration by Regulating the Activation of Signal Transducer and Activator of Transcription 3 and NF-κB

Dai, Xiuju; Shiraishi, Ken; Muto, Jun; Mori, Hideki; Murakami, Masamoto; Sayama, Koji

doi:10.1016/j.xjidi.2023.100205

Cited by 2 publications

(1 citation statement)

References 70 publications

(107 reference statements)

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“…The integrity of the skin barrier is determined by a specialized, stratified structural protein complex, the efficacy of which is contingent upon the interplay among transglutaminase-crosslinked proteins, including filaggrin (FLG), loricrin (LOR), and transglutaminase-1 (TGM1) [72][73][74][75]. Several studies have shown that deficiencies in FLG, LOR, and TGM1 result in skin disorders like dryness, flaking, lipid changes, and allergies [76][77][78][79][80]. Aquaporins (AQPs) are a class of integral membrane proteins that modulate water movement across the plasma membrane, thus contributing to the regulation of water homeostasis in the epidermis [81][82][83].…”

Section: Skin and Hair Care Properties Of Melsmentioning

confidence: 99%

Promising Application, Efficient Production, and Genetic Basis of Mannosylerythritol Lipids

Liu,

Liu

2024

Biomolecules

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Mannosylerythritol lipids (MELs) are a class of glycolipids that have been receiving increasing attention in recent years due to their diverse biological activities. MELs are produced by certain fungi and display a range of bioactivities, making them attractive candidates for various applications in medicine, agriculture, and biotechnology. Despite their remarkable qualities, industrial-scale production of MELs remains a challenge for fungal strains. Excellent fungal strains and fermentation processes are essential for the efficient production of MELs, so efforts have been made to improve the fermentation yield by screening high-yielding strains, optimizing fermentation conditions, and improving product purification processes. The availability of the genome sequence is pivotal for elucidating the genetic basis of fungal MEL biosynthesis. This review aims to shed light on the applications of MELs and provide insights into the genetic basis for efficient MEL production. Additionally, this review offers new perspectives on optimizing MEL production, contributing to the advancement of sustainable biosurfactant technologies.

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Section: Skin and Hair Care Properties Of Melsmentioning

confidence: 99%

Promising Application, Efficient Production, and Genetic Basis of Mannosylerythritol Lipids

Liu,

Liu

2024

Biomolecules

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Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

Lui,

Xu,

Aziz

et al. 2024

Preprint

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Skin-resident regulatory T cells (Tregs) play an irreplaceable role in orchestrating cutaneous immune homeostasis and repair, including the promotion of hair regeneration via the Notch signaling ligand Jagged-1 (Jag1). While skin Tregs are indispensable for facilitating tissue repair post-wounding, it remains unknown if Jag1-expressing skin Tregs impact wound healing. Using a tamoxifen inducible Foxp3creERT2Jag1fl/flmodel, we show that loss of functional Jag1 in Tregs significantly delays the rate of full-thickness wound closure. Unlike in hair regeneration, skin Tregs do not utilize Jag1 to impact epithelial stem cells during wound healing. Instead, mice with Treg-specific Jag1 ablation exhibit a significant reduction in Ly6G+ neutrophil accumulation at the wound site. However, during both homeostasis and wound healing, the loss of Jag1 in Tregs does not impact the overall abundance or activation profile of immune cell targets in the skin, such as CD4+ and CD8+ T cells, or pro-inflammatory macrophages. This collectively suggests that skin Tregs may utilize Jag1-Notch signalling to co-ordinate innate cell recruitment under conditions of injury but not homeostasis. Overall, our study demonstrates the importance of Jag1 expression in Tregs to facilitate adequate wound repair in the skin.

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Nuclear IL-33 Plays an Important Role in EGFR-Mediated Keratinocyte Migration by Regulating the Activation of Signal Transducer and Activator of Transcription 3 and NF-κB

Cited by 2 publications

References 70 publications

Promising Application, Efficient Production, and Genetic Basis of Mannosylerythritol Lipids

Promising Application, Efficient Production, and Genetic Basis of Mannosylerythritol Lipids

Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

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