Nuclear Hmgb1

Raucci, Angela; Capogrossi, Maurizio C.

doi:10.1016/j.jacbts.2019.03.008

Cited by 3 publications

(1 citation statement)

References 18 publications

(31 reference statements)

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“…It was shown that cytosolic HMGB1 binding TLR9 improves tissue repair, increased wound healing, and angiogenesis [ 88 ]. Raucci and colleagues [ 89 ] showed that protective or harmful effects of HMGB1 and TLR9 might finally dependent on the concentration of HMGB1. Hence, future studies are required to understand the detailed interaction of DNA-binding proteins to cfDNA and their impact on the resulting immunological function after tissue injury.…”

Section: Immune Sensing Of Cfdnamentioning

confidence: 99%

The role of circulating cell-free DNA as an inflammatory mediator after stroke

2023

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Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex role of the immune system in the pathophysiology of stroke. Ischemic brain injury leads to the release of cell-free DNA, a damage-associated molecular pattern, which binds to pattern recognition receptors on immune cells such as toll-like receptors and cytosolic inflammasome sensors. The downstream signaling cascade then induces a rapid inflammatory response. In this review, we are highlighting the characteristics of cell-free DNA and how these can affect a local as well as a systemic response after stroke. For this purpose, we screened literature on clinical studies investigating cell-free DNA concentration and properties after brain ischemia. We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.

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Section: Immune Sensing Of Cfdnamentioning

confidence: 99%

The role of circulating cell-free DNA as an inflammatory mediator after stroke

2023

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HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases

Zheng

Liu

et al. 2023

Biomedicine & Pharmacotherapy

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An overview of high-mobility group box 1, a potent pro-inflammatory cytokine in asthma

Kianian

Kadkhodaee

Sadeghipour

et al. 2020

Journal of Basic and Clinical Physiology and Pharmacology

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High-mobility group box 1 (HMGB1), also called amphoterin, HMG1 and p30, is a highly conserved protein between different species that has various functions in nucleus such as stabilization of nucleosome formation, facilitation of deoxyribonucleic acid (DNA) bending and increasing the DNA transcription, replication and repair. It has also been indicated that HMGB1 acts as a potent pro-inflammatory cytokine with increasing concentrations in acute and chronic inflammatory diseases. Asthma is a common chronic respiratory disease associated with high morbidity and mortality rates. One central characteristic in its pathogenesis is airway inflammation. Considering the inflammatory role of HMGB1 and importance of inflammation in asthma pathogenesis, a better understanding of this protein is vital. This review describes the structure, cell surface receptors, signaling pathways and intracellular and extracellular functions of HMGB1, but also focuses on its inflammatory role in asthma. Moreover, this manuscript reviews experimental and clinical studies that investigated the pathologic role of HMGB1.

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Nuclear Hmgb1

Abstract: Corresponding Author

Cited by 3 publications

References 18 publications

The role of circulating cell-free DNA as an inflammatory mediator after stroke

The role of circulating cell-free DNA as an inflammatory mediator after stroke

HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases

An overview of high-mobility group box 1, a potent pro-inflammatory cytokine in asthma

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