Nuclear fragments and holes in grading of breast cancer aspirates

Abodief, W. T.; Dey, Pranab; Al-Hattab, O.; Al-Jassar, Aisha

doi:10.1111/j.1365-2303.2006.00332.x

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Both PTC and MBC may demonstrate enlarged and crowded nuclei with nucleoli. In contrast to nuclear pseudoinclusions which possess the color of the cytoplasm, MBC may exhibit colorless intranuclear “holes” due to mechanical distortion or air bubbles …”

Section: Discussionmentioning

confidence: 99%

Metastatic ductal carcinoma of the breast to the thyroid gland diagnosed with fine needle aspiration: A case report with emphasis on morphologic and immunophenotypic features

Magers

Dueber

Lew

et al. 2016

Diagnostic Cytopathology

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Metastases to the thyroid are uncommon [<0.2% of thyroid fine needle aspirations (FNA)]. Of metastases to the thyroid, breast carcinoma is relatively common. The diagnosis of metastasis to the thyroid has important therapeutic and prognostic implications. To our knowledge, a morphologic and immunophenotypic comparison of metastatic ductal carcinoma of the breast and primary thyroid carcinomas has not been reported. Here, we report the case of a 37-year-old female with a history of metastatic ductal carcinoma of the breast (modified Bloom-Richardson grade 2; ER+, PgR+, HER2+) diagnosed 6 years prior. She developed hoarseness, prompting a CT scan. Multiple thyroid nodules were found, including a 1.5 cm hypoechoic, solid, irregularly-shaped nodule. On FNA, cells were arranged singly and in crowded groups, varied in size and degree of pleomorphism, and exhibited rare nuclear grooves, inconspicuous nucleoli, and rare intracytoplasmic lumina with no nuclear pseudoinclusions or colloid (Figs. 1A and B). These findings raised the differential of papillary thyroid carcinoma (Fig. 1C), follicular neoplasm (Fig. 1D), medullary carcinoma (Fig. 1E), parathyroid (Fig. 1F), and metastatic breast carcinoma. Immunostaining for GATA-3 (+), ER (+), PAX-8 (-), and TTF-1 (-) was consistent with metastatic breast carcinoma (Fig. 2). We conclude that metastatic breast carcinoma to the thyroid may morphologically mimic primary thyroid carcinoma on FNA; a panel of immunomarkers, such as GATA-3, hormonal marker(s), PAX-8, and TTF-1, may be useful in some cases. GATA-3 immunostaining for metastatic breast carcinoma was helpful in our case and has not been previously reported in a thyroid metastasis sampled by FNA. Diagn. Cytopathol. 2016;44:530-534. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Metastatic ductal carcinoma of the breast to the thyroid gland diagnosed with fine needle aspiration: A case report with emphasis on morphologic and immunophenotypic features

Magers

Dueber

Lew

et al. 2016

Diagnostic Cytopathology

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“…There are only limited numbers of studies available that mention the MN scoring in breast lesions. Abodief et al 9 first observed nuclear fragmentation as a separately lying intracytoplasmic dot of the same texture and staining property as the original nucleus. They also noted a statistically significant increase in nuclear fragmentation with increase in tumour grade.…”

Section: Discussionmentioning

confidence: 99%

“…8 However, limited studies are available on MN score in primary epithelial cells of malignant and benign breast lesions. 9 In the present study we scored and compared MN in benign (fibroadenoma) and malignant (infiltrating duct carcinoma) breast lesions to evaluate the role of MN as a biomarker in breast carcinomas. We also compared MN scores among different cytological grades of breast carcinoma.…”

Section: Introductionmentioning

confidence: 99%

The role of micronucleus scoring in fine needle aspirates of ductal carcinoma of the breast

2011

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“…However the nuclear holes are of variable sized clear spaces and the outer boundary of the hole is not sharp. 30…”

Section: Discussionmentioning

confidence: 99%

Intranuclear peudoinclusions: Morphology, pathogenesis, and significance

Arora

Dey

2011

Diagnostic Cytopathology

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Intranuclear pseudoinclusions represent invaginations of the cytoplasm into the nucleus. The nuclear pseudoinclusions are generally easier to appreciate in cytological preparations than frozen sections or histopathology thus forming an important cytological feature. In the present article we have reviewed the morphology, pathogenesis, differential diagnosis, and clinical significance of intranuclear cytoplasmic pseudoinclusion.

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Nuclear fragments and holes in grading of breast cancer aspirates

Cited by 4 publications

References 3 publications

Metastatic ductal carcinoma of the breast to the thyroid gland diagnosed with fine needle aspiration: A case report with emphasis on morphologic and immunophenotypic features

Metastatic ductal carcinoma of the breast to the thyroid gland diagnosed with fine needle aspiration: A case report with emphasis on morphologic and immunophenotypic features

The role of micronucleus scoring in fine needle aspirates of ductal carcinoma of the breast

Intranuclear peudoinclusions: Morphology, pathogenesis, and significance

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