Nuclear fractal dimension as a prognostic factor in oral squamous cell carcinoma

Goutzanis, Lampros; Papadogeorgakis, Nikolaos; Pavlopoulos, Petros M.; Katti, Kattesh V.; Petsinis, Vassilis; Ioannis, Plochoras; Pantelidaki, Catherine; Kavantzas, Nikolaos; Patsouris, Efstratios; Alexandridis, Constantinos

doi:10.1016/j.oraloncology.2007.04.005

Cited by 52 publications

(47 citation statements)

References 20 publications

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“…Previous studies suggest that there is less interobserver variability with fractal analysis by image analysis than with the semiquantitative score (18 (22). In a previous study FD was used as a prognostic factor for laryngeal carcinoma, in an other study Goutzanis and his team proved that increased FD for cellular elements is inversely correlated with survival in oral cancer (23,24). Also some studies also theorized on the usage of FD in cancer prognosis (25,26).…”

Section: Discussionmentioning

confidence: 99%

The Detection of Fractal Dimension With Protective Effects of Lycopene and Catechin Carbon Tetrachloride-Treated Rat's Liver

Kurt¹,

Özden²,

Demır³

et al. 2015

Osmangazi̇ Journal of Medicine

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Our aim is to investigate the detection of fractal dimension (Box-counting dimensions) with protective effects of lycopene and catechin in carbon tetrachloride-treated rat's liver. Fractal dimension measure intensity and complexity of subject. The rats were divided into six groups as liquid oil, lycopene, catechin, carbon tetrachloride plus lycopene, carbon tetrachloride plus catechin and carbon tetrachloride. The tissue samples were obtained at end of 2İst day. The liver tissue distortions were evaluated using hematoxylin and eosin staining. The regions of hepatocyte were separated into Small Square under light microscopy. Then, counted at least one nucleus with intersection of one square. Fractal dimension were determined by using this formula; ln(N(n))/ln(2 n ). Notably, there was no difference between control and catechin-treated rats on fractal dimension values. But, a lycopene value was bigger than control and catechin administrated rats. In carbon tetrachloride-treated rat, fractal dimension is less. It was increased in lycopene plus carbon tetrachloride and catechin plus carbon tetrachloride with compare to carbon tetrachloride group. The findings confirmed, if hepatocyte is less, fractal dimension will decrease On other hand, carbon tetrachloride decreased fractal dimension due to less hepatocyte. It was increased in fractal dimension due to high hepatocyte in catechin and lycopene treated rats, because of their protective effects. This study is combination of medicine and mathematics, as fractal dimension. It was calculated, toxicity and protective effects of antioxidant materials could be determined in this way. KEY WORDS: CCl4, Lycopene, catechin, Fractal dimension ÖZET: Amacımız karbon tetraklorür uygulanmış sıçan karaciğerinde likopen ve kateşinin koruyucu etkilerinin fraktal boyut hesaplaması kullanılarak ortaya konmasıdır. Fraktal boyut nesnenin yoğunluğunu ve karmaşıklığını ölçer. Sıçanlar; sıvı yağ, likopen, kateşin, karbon tetraklorür + likopen, karbon tetraklorür + kateşin ve karbon tetraklorür olmak üzere altı gruba ayrıldı. Doku örnekleri 21. gün sonunda elde edildi. Karaciğer dokusundaki harabiyet, hematoksilen ve eozin boyama ile değerlendirildi. Hepatosit bölgeleri ışık mikroskobu altında küçük karelere ayrıldı. Sonra en az bir nükleusun bir kareyle kesiştiği alan sayıldı. Fraktal boyut ln(N(n))/ln(2 n ) formülle hesaplandı. Özellikle, fraktal boyut değerleri açısından kontrol ve kateşin ile tedavi edilen gruplar arasında bir fark yoktu. Ama likopen değerleri kontrol ve kateşin uygulanan sıçanlarda daha yüksek bulundu. Karbon tetraklorür uygulanmış sıçanlarda fraktal boyut düşüktü. Karbon tetraklorür uygulanmış gruba göre karbon tetraklorür + likopen ve karbon tetraklorür + kateşin gruplarında fraktal boyutta artış gözlendi. Bulgular hepatosit miktarındaki azalmaın, fraktal boyutun azalmaya neden olacağını göstermiştir. Diğer taraftan, karbon tetraklorür hepatositlerin az olması nedeniyle fraktal boyutu azaltmıştır. Kateşin ve likopen uygulanan gruplarda yüksek hepatosit miktar...

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Section: Discussionmentioning

confidence: 99%

The Detection of Fractal Dimension With Protective Effects of Lycopene and Catechin Carbon Tetrachloride-Treated Rat's Liver

Kurt¹,

Özden²,

Demır³

et al. 2015

Osmangazi̇ Journal of Medicine

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“…Goutzanis et al [118] studied the FD of nuclei in tissue from patients with oral squamous cell carcinoma (OSCC). Their technique was performed on histological sections (see Fig.…”

Section: Cancermentioning

confidence: 99%

Fractals in dentistry

Sánchez¹,

Uzcátegui²

2011

Journal of Dentistry

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“…The determination of fractality characterizes the complexity of a structure not revealed by classical morphometry. The fractal nature of nuclear chromatin and of the surrounding nucleoplasmic space (Lieberman-Aiden et al, 2009;Bancaud A et al, 2009) are of prognostic importance in neoplasias (Goutzanis et al, 2008;Mashiah et al, 2008). Unstable, aggressive tumors with a high number of genetic or epigenetic changes, are characterized by a complex chromatin rearrangement, with an increased number of darker and lighter areas.…”

Section: Chromatin Texturementioning

confidence: 99%

Genetic, Epigenetic and Molecular Changes in Melanoma: A New Paradigm for Biological Classification

Staibano¹,

Mascolo²,

Siano³

et al. 2011

Research on Melanoma - A Glimpse Into Current Directions and Future Trends

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Nuclear fractal dimension as a prognostic factor in oral squamous cell carcinoma

Cited by 52 publications

References 20 publications

The Detection of Fractal Dimension With Protective Effects of Lycopene and Catechin Carbon Tetrachloride-Treated Rat's Liver

The Detection of Fractal Dimension With Protective Effects of Lycopene and Catechin Carbon Tetrachloride-Treated Rat's Liver

Fractals in dentistry

Genetic, Epigenetic and Molecular Changes in Melanoma: A New Paradigm for Biological Classification

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