Nuclear fluorination of 2,4-diarylthiazoles with Accufluor®

Transition‐Metal‐Free Oxidative Iodination of 1,3,4‐Oxadiazoles

“…With NaBr (instead of NaI), corresponding brominated product 5 was only observed in trace quantities, and to our surprise, chlorination of 1a occurred. Apparently, Selectfluor served as a halide source, and as a result chlorinated 1,3,4‐oxadiazole 6 was formed in 30 % yield 23. Substituting NaI with NaCl led to the same product (i.e., 6 ) in 33 % yield 24…”

Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

“…The importance of fluorinated heterocyclic derivatives in the pharmaceutical and agrochemical industries continues to grow, with several fluorinated 6-membered heteroaromatic derivatives finding applications in a wide variety of drugs and plantprotective agents [15][16][17][18][19][20][21][22][23][24][25][26][27]. However, there are only a few reports on the synthesis and properties of fluorinated 5-membered heteroaromatic systems, especially those comprising two heteroatoms such as pyrazoles [28,29], isoxazoles [30], and thiazoles [31,32]. Recently, we reported the selective fluorination of isoxazoles, to give monofluorinated isoxazoles 3 or trifluorinated isoxazolines 4 in moderate to good yields (Scheme 1) [33].…”

Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

“…On the other hand, many fluorinated 6-membered heteroaromatic derivatives find applications in a wide variety of drugs and plant protective materials and, consequently, there are several examples of the synthesis of fluorinated 6-membered heteroaromatic rings by selective fluorination strategies. [15][16][17][18][19][20][21][22][23][24][25][26][27] However, selective fluorination of 5membered heteroaromatic systems are rare and, in particular, there are only a few reports concerning the synthesis of fluorinated 5-membered heteroaromatic systems that have two heteroatoms, such as pyrazoles [28,29], isoxaoles [30] and thiazoles [31,32]. We recently reported selective fluorination of isoxazoles to give mono-fluorinated isoxazoles (3) or tri-fluorinated isoxazolines (4) in moderate to good yields (Scheme 1).…”