Nuclear factor-κB plays an important role in Tamarixetin-mediated inhibition of matrix metalloproteinase-9 expression

Shaji, Sanu K.; Drishya, G; Sunilkumar, Damu; Nanjan, Pandurangan; Kumar, Geetha B.; Nair, Bipin G.

doi:10.1016/j.ejphar.2020.173808

Cited by 10 publications

(9 citation statements)

References 40 publications

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“…Tamarixetin is a naturally occurring flavonoid reported to possess anti-cancer, anti-metastatic, anti-inflammatory, cardioprotective and gastroprotective activities. Earlier studies from our laboratory had demonstrated the antimetastatic potential of Tamarixetin in Fibrosarcoma cells 22 . Tamarixetin was shown to inhibit cell proliferation and induce apoptosis in HepG2 liver cancer cells 26 and in K562 human leukemia cells 27 .…”

Section: Discussionmentioning

confidence: 91%

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Systematic understanding of anti-tumor mechanisms of Tamarixetin through network and experimental analyses

Shaji

Drishya

Sunilkumar

et al. 2022

Sci Rep

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Tamarixetin, a flavonoid derived from Quercetin, was shown to possess anti-cancer properties in various types of cancer. However, the mechanism of action of this compound is not well understood. Observations from reverse docking and network pharmacology analysis, were validated by cell based studies to analyse the chemotherapeutic potential and elucidate the molecular mechanism of action of Tamarixetin in breast cancer. In silico analysis using reverse docking and PPI analysis clearly indicated that out of 35 proteins targeted by Tamarixetin, the top 3 hub genes, namely, AKT1, ESR1 and HSP90AA1, were upregulated in breast tumor tissues and more importantly showed strong negative correlation to breast cancer patient survival. Furthermore, the KEGG pathway analysis showed enrichment of target proteins of Tamarixetin in 33 pathways which are mainly involved in neoplastic signalling. In vitro cell-based studies demonstrated that Tamarixetin could inhibit cell proliferation, induce ROS and reduce mitochondrial membrane potential, leading to cell death. Tamarixetin induced cell cycle arrest at G2/M phase and inhibited the migration as well as the invasion of breast cancer cells. Taken together, the combination of in silico and in vitro approaches used in the present study clearly provides evidence for the chemotherapeutic potential of Tamarixetin in breast cancer.

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Section: Discussionmentioning

confidence: 91%

“…Earlier studies from our laboratory had shown Tamarixetin, a naturally occurring flavonoid, to have anticancer as well as anti-metastatic properties in HT1080 cells 22 . Furthermore, Tamarixetin has also been shown to have antioxidant properties 23 .…”

Section: Openmentioning

confidence: 98%

Systematic understanding of anti-tumor mechanisms of Tamarixetin through network and experimental analyses

Shaji

Drishya

Sunilkumar

et al. 2022

Sci Rep

Self Cite

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“…Among these drugs, four NF-κB inhibitors, namely, isoliquiritigenin, isorhamnetin, parthenolide, and rutin, prevented inflammatory responses and inhibited the development of endometriosis in preclinical studies [97,[125][126][127]. Other drugs, including dehydroxymethylepoxyquinomicin, edasalonexent, acacetin, artesunate, chrysoeriol, cudraflavone B, cynaropicrin, N-(3-oxododecanoyl) homoserine lactone, quercetagetin, sorbinil, tamarixetin, diosmetin, laquinimod, and triptolide, also have inhibitory effects on the NF-κB signaling-induced inflammatory response; thus, their effects on endometriosis need further exploration [128][129][130][131][132][133][134][135][136].…”

Section: Potential Drugsmentioning

confidence: 99%

An Update on the Multifaceted Role of NF-kappaB in Endometriosis

2022

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Endometriosis remains a common but challenging gynecological disease among reproductive-aged women with an unclear pathogenesis and limited therapeutic options. Numerous pieces of evidence suggest that NF-κB signaling, a major regulator of inflammatory responses, is overactive in endometriotic lesions and contributes to the onset, progression, and recurrence of endometriosis. Several factors, such as estrogen, progesterone, oxidative stress, and noncoding RNAs, can regulate NF-κB signaling in endometriosis. In the present review, we discuss the mechanisms by which these factors regulate NF-κB during endometriosis progression and provide an update on the role of NF-κB in affecting endometriotic cells, peritoneal macrophages (PMs) as well as endometriosis-related symptoms, such as pain and infertility. Furthermore, the preclinical drugs for blocking NF-κB signaling in endometriosis are summarized, including plant-derived medicines, NF-κB inhibitors, other known drugs, and the potential anti-NF-κB drugs predicted through the Drug-Gene Interaction Database. The present review discusses most of the studies concerning the multifaceted role of NF-κB signaling in endometriosis and provides a summary of NF-κB-targeted treatment in detail.

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“…Numerous works proved various anticancer effects of flavonoids. For example, quercetin can reduce can activity of a nuclear factor kappa B and expression of the Pglycoprotein and thereby angiogenesis and multidrug resistance and cell migration [12][13][14]. Similarly, Gates et al publish, that kaempferol can significantly decrease a risk of ovarian cancer [15].…”

Section: Introductionmentioning

confidence: 99%

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

Kejík

Kaplánek

Masařík

et al. 2021

IJMS

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Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.

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Nuclear factor-κB plays an important role in Tamarixetin-mediated inhibition of matrix metalloproteinase-9 expression

Cited by 10 publications

References 40 publications

Systematic understanding of anti-tumor mechanisms of Tamarixetin through network and experimental analyses

Systematic understanding of anti-tumor mechanisms of Tamarixetin through network and experimental analyses

An Update on the Multifaceted Role of NF-kappaB in Endometriosis

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

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