Nuclear factor‐kappa B as a promising target for selenium chemoprevention in rat hepatocarcinogenesis

Alwahaibi, Nasar; Budin, Siti Balkis; Mohamed, Jamaludin; Al-Hamdani, Aisha

doi:10.1111/j.1440-1746.2009.06160.x

Cited by 9 publications

(2 citation statements)

References 26 publications

(52 reference statements)

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“…Additionally, evidence indicates that supplementing with supranutritional selenium can modulate specific pathological changes via various mechanisms, including GPx and TrxR suppressing NF-κB activation and its inflammatory reactions. [166][167][168][169]. Genetic studies have shown that a single nucleotide polymorphism (SNP) at codon 198 of GPx1 is associated with low bone mineral density and increase in the levels of bone turnover markers [170].…”

Section: Selenoproteins In Bone Metabolismmentioning

confidence: 99%

The Effects of Selenium on Bone Health: From Element to Therapeutics

et al. 2022

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Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversial. Selenium, an important trace element, is required for selenoprotein synthesis and acts crucially for proper growth and skeletal development. However, the intake of an optimum amount of selenium is critical, as both selenium deficiency and toxicity are hazardous for health. In this review, we have systematically analyzed the existing literature in this field to determine whether dietary or serum selenium concentrations are associated with bone health. In addition, the mode of administration of selenium as a supplement for treating bone disease is important. We have also highlighted the importance of using green-synthesized selenium nanoparticles as therapeutics for bone disease. Novel nanobiotechnology will be a bridgehead for clinical applications of trace elements and natural products.

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Section: Selenoproteins In Bone Metabolismmentioning

confidence: 99%

The Effects of Selenium on Bone Health: From Element to Therapeutics

et al. 2022

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“…1 Previous studies have shown that it is sufficient to inhibit the development of certain cancers by daily supplementation of 200 μg selenium. 2 Selenium can also reduce the risk of cardiovascular diseases. 3,4 Some researchers have found that selenium can decrease the activity of brain monoamine oxidase B (MAO-B) in adult rats and slow down the aging process.…”

Section: Introductionmentioning

confidence: 99%

Selenium Supplementation Can Slow the Development of Naphthalene Cataract

Zhu

Lü

2012

Current Eye Research

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The Inflammation and Liver Cancer

Bishayee

2014

Advances in Experimental Medicine and Biology

234

172

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Persistent inflammation is known to promote and exacerbate malignancy. Primary liver cancer, mostly hepatocellular carcinoma (HCC), is a clear example of inflammation-related cancer as more than 90 % of HCCs arise in the context of hepatic injury and inflammation. HCC represents the fifth most common malignancy and the third leading cause of cancer-related death worldwide with about one million new cases diagnosed every year with almost an equal number of deaths. Chronic unresolved inflammation is associated with persistent hepatic injury and concurrent regeneration, leading to sequential development of fibrosis, cirrhosis, and eventually HCC. Irrespective of the intrinsic differences among various etiological factors, a common denominator at the origin of HCC is the perpetuation of a wound-healing response activated by parenchymal cell death and the resulting inflammatory cascade. Hence, the identification of fundamental inflammatory signaling pathways causing transition from chronic liver injury to dysplasia and HCC could depict new predictive biomarkers and targets to identify and treat patients with chronic liver inflammation. This chapter critically discusses the roles of several major cytokines, chemokines, growth factors, transcription factors, and enzymes as well as a distinct network of inflammatory signaling pathways in the development and progression of HCC. It also highlights and analyzes preclinical animal studies showing innovative approaches of targeting inflammatory mediators and signaling by a variety of natural compounds and synthetic agents to achieve effective therapy as well as prevention of hepatic malignancy. Additionally, current limitations and potential challenges associated with the inhibition of inflammatory signaling as well as future directions of research to accelerate clinical development of anti-inflammatory agents to prevent and treat liver cancer are presented.

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Nuclear factor‐kappa B as a promising target for selenium chemoprevention in rat hepatocarcinogenesis

Abstract: The inhibition of the NF-kappaB pathway in the initiation phase of hepatocarcinogenesis could be a promising target for selenium chemoprevention. However, further studies are required.

Cited by 9 publications

References 26 publications

The Effects of Selenium on Bone Health: From Element to Therapeutics

The Effects of Selenium on Bone Health: From Element to Therapeutics

Selenium Supplementation Can Slow the Development of Naphthalene Cataract

The Inflammation and Liver Cancer

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