Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer

Becker‐Santos, Daiana D.; Lonergan, Kim M.; Gronostajski, Richard M.; Lam, Wan L.

doi:10.1016/j.ebiom.2017.05.027

Cited by 57 publications

(64 citation statements)

References 65 publications

(88 reference statements)

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“…Most recently, NFIB has been shown to promote proliferation of breast cancer cells in the absence of estrogen and inhibit the transcription activity of ERα [18]. Consistent with the previous study that NFIA promotes growth of ESCC cells [11], we show here that NFIA is overexpressed in ESCC tissues, and high NFIA expression correlates with poor differentiation, lymph node metastasis, and advanced TNM stage in ESCC. It is worth noting that although NFIB was also overexpressed in ESCC, it is of no clinicopathological value in ESCC.…”

Section: Discussionsupporting

confidence: 92%

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma

Yang

Zhou

Chen³

et al. 2018

Cancer Medicine

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The nuclear factor I (NFI) family members, especially NFIA and NFIB, play essential roles in cancers. The roles of NFIA and NFIB in esophageal squamous cell carcinoma (ESCC) and esophagogastric junction adenocarcinoma (EJA) remain poorly known. This study aimed to determine the expression of NFIA and NFIB in ESCC and EJA and elucidate their prognostic significance. The expression of NFIA and NFIB was examined in 163 ESCC samples and 26 EJA samples by immunohistochemistry. The results showed that high NFIA expression correlated significantly with poor differentiation, lymph node metastasis, and advanced TNM stage in patients with ESCC. High NFIB expression only correlated with poor differentiation in patients with ESCC. Survival analysis showed that NFIA but not NFIB associated with short overall survival (OS) and disease‐free survival (DFS) of patients with ESCC. On the other hand, high NFIB expression correlated with lymph node metastasis, advanced TNM stage, and short OS and DFS in patients with EJA. Finally, multivariate analysis demonstrated that high NFIA expression was an independent prognostic factor for ESCC. Taken together, these results demonstrated that NFIA and NFIB could serve as prognostic indicators for ESCC and EJA, respectively.

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Section: Discussionsupporting

confidence: 92%

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma

Yang

Zhou

Chen³

et al. 2018

Cancer Medicine

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“…Chen et al, 2017). In a recent study in female Becker-Santos, Lonergan, Gronostajski, & Lam, 2017). While the study of de Melo et al (2019) did not specifically address adhesion molecules it did illustrates the importance of early reproductive events in determining reproductive outcome.…”

Section: Adhesion Molecules and Reproduction In Cattlementioning

confidence: 99%

“…For example, SNPs in the l ‐selectin gene cluster were associated with fertility and longevity in Holstein Friesian cows (X. Chen et al, 2017). In a recent study in female Brahman and Nellore cattle (de Melo, Fortes, Hayes, de Albuquerque, & Carvalheiro, 2019), SNPs associated with fertility were linked with blastocyst development (genes GCGN , ATF6B ; Gad et al, 2011), embryonic development (genes NF1B , NAPA , ZPR1 , TAF8 , HEX1M1 , HEX1M2 ; Mamo et al, 2011; Al Naib, Mamo, & Lonergan, 2012), uterine function (genes C11H2orf49 , CCND3 ; Hayashi et al, 2017), and general cell proliferation and morphogenesis (gene CHSY1 ; Becker‐Santos, Lonergan, Gronostajski, & Lam, 2017). While the study of de Melo et al (2019) did not specifically address adhesion molecules it did illustrates the importance of early reproductive events in determining reproductive outcome.…”

Section: Adhesion Molecules and Reproduction In Cattlementioning

confidence: 99%

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

D’Occhio

Campanile

Zicarelli

et al. 2020

Molecular Reproduction Devel

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Cell–cell adhesion molecules have critically important roles in the early events of reproduction including gamete transport, sperm–oocyte interaction, embryonic development, and implantation. Major adhesion molecules involved in reproduction include cadherins, integrins, and disintegrin and metalloprotease domain‐containing (ADAM) proteins. ADAMs on the surface of sperm adhere to integrins on the oocyte in the initial stages of sperm–oocyte interaction and fusion. Cadherins act in early embryos to organize the inner cell mass and trophectoderm. The trophoblast and uterine endometrial epithelium variously express cadherins, integrins, trophinin, and selectin, which achieve apposition and attachment between the elongating conceptus and uterine epithelium before implantation. An overview of the major cell–cell adhesion molecules is presented and this is followed by examples of how adhesion molecules help shape early reproductive events. The argument is made that a deeper understanding of adhesion molecules and reproduction will inform new strategies that improve embryo survival and increase the efficiency of natural mating and assisted breeding in cattle.

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“…However, other studies report that NFIB serve as an oncogene in small cell lung cancer, melanoma and triple negative breast cancer, while NFIB inhibits tumor development and progression in glioma, glioblastoma and osteosarcoma. 7 Nevertheless, studies of NFIB in CRC are rare, and the biological function of NFIB in CRC is still unclear.…”

mentioning

confidence: 99%

Nuclear factor I/B promotes colorectal cancer cell proliferation, epithelial‐mesenchymal transition and 5‐fluorouracil resistance

et al. 2018

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Nuclear factor I/B (NFIB) is a widely studied transcription factor that participates in tumor progression; nevertheless, studies on NFIB in colorectal cancer (CRC) are limited. In our study, Western blot and RT‐PCR analyses showed that NFIB was overexpressed in CRC tissues and cell lines, which was consistent with our bioinformatic analysis results. Furthermore, NFIB expression was closely related to the TNM stage of CRC. NFIB promoted cell proliferation and migration and inhibited cell apoptosis in vitro. Meanwhile, we discovered that NFIB accelerated xenograft tumor growth in vivo. In addition, NFIB weakened the sensitivity of CRC cells to 5‐fluorouracil (5‐FU). NFIB induced epithelial‐mesenchymal transition (EMT) by upregulating snail expression, which was accompanied by decreased E‐cadherin and Zo‐1 expression and increasedd Vimentin expression. Because the Akt pathway plays an important role in CRC progression, we examined whether there was a correlation between NFIB and the Akt pathway in cell proliferation and migration. Our results showed that NFIB promoted cell proliferation and increased 5‐FU resistance by activating the Akt pathway. In summary, our findings suggested that NFIB induced EMT of CRC cells via upregulating snail expression and promoted cell proliferation and 5‐FU resistance by activating the Akt pathway.

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Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer

Cited by 57 publications

References 65 publications

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

Nuclear factor I/B promotes colorectal cancer cell proliferation, epithelial‐mesenchymal transition and 5‐fluorouracil resistance

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