Nuclear factor erythroid 2-related factor 2 (Nrf2), tumor necrosis factor alpha protein (TNF-α), heme oxygenase-1 (HO-1) gene expressions during cardiopulmonary bypass

Ayıkgöz, Yusuf; Aydın, Mehmet Salih; Kankılıç, Nazım; Temiz, Ebru

doi:10.1016/j.gene.2021.145690

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…In this study significant lower levels of TNF-α in the SG compared to control at the end of experiment are shown. This anti-inflammatory effect is well known [23][24][25] . In the pathophysiology of the VS cytokine storm leading to NO release is discussed as the main cause of hypotension 13,14 .…”

Section: Discussionmentioning

confidence: 90%

Vasoplegic syndrome in cardiovascular surgery; evaluating effects of Sevoflurane and Glibenclamide in a porcine model

Winter

Nepper

Hermann

et al. 2023

Preprint

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Background: Vasoplegic syndrome is frequently observed during cardiac surgery and resembles a complication of high mortality and morbidity. There is a clinical need for therapy and prevention of vasoplegic syndrome during complex cardiac surgical procedures. Therefore, we investigated different strategies in a porcine model of vasoplegia. Methods: We evaluated new medical therapies and prophylaxis to avoid vasoplegic syndrome in a porcine model. After induction of anesthesia, cardiopulmonary bypass was established through median sternotomy and central cannulation. Prolonged aortic cross-clamping (120 min) simulated a complex surgical procedure. The influence of sevoflurane-guided anesthesia (sevoflurane group) and the administration of glibenclamide (glibenclamide group) were compared to a control group, which received standard anesthesia using propofol. Online hemodynamic assessment was performed using PiCCO® measurements. In addition, blood and tissue samples were taken to evaluate hemodynamic effects and the degree of inflammatory response. Results: Glibenclamide was able to break through early vasoplegic syndrome by raising the blood pressure and systemic vascular resistance as well as less need of norepinephrine doses. Sevoflurane reduced the occurrence of the vasoplegic syndrome in the mean of stable blood pressure and less need of norepinephrine doses. Conclusion: Glibenclamide could serve as a potent drug to reduce effects of vasoplegic syndrome. Sevoflurane anesthesia during cardiopulmonary bypass shows less occurrence of vasoplegic syndrome and therefore could be used to prevent it in high-risk patients.

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Section: Discussionmentioning

confidence: 90%

Vasoplegic syndrome in cardiovascular surgery; evaluating effects of Sevoflurane and Glibenclamide in a porcine model

Winter

Nepper

Hermann

et al. 2023

Preprint

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“…In non-neutrophil-mediated injury, circulating pro-inflammatory cytokines (TNFa and IL-1) directly stimulate endothelial cells, leading to a pathological increase in permeability, causing tissue edema and impaired oxygen exchange, causing multiorgan dysfunction [45].…”

Section: Endothelial Injurymentioning

confidence: 99%

“…These regulatory mechanisms of vasoconstriction are deregulated, to a greater or lesser extent, during and after the cardiopulmonary bypass ends (Figure 3). The passage of blood through CPB stimulates the activation of the complement cascade, production of ROS species and release of inflammatory mediators, such as the triad of cytokines, interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) [45,[75][76][77][78]. All this inflammatory biochemistry is capable of acting in specific areas of the brain such as the locus coeruleus and the paraventricular nucleus of the hypothalamus, where the cells responsible for the hypothalamic-pituitary-adrenal axis are located; they stimulate these regions and lead to a reduction and desensitization of the alpha-1 adrenergic receptor and an increase in the inflammatory state, thus forming a cycle that is difficult to overcome (11).…”

Section: Vasoplegiamentioning

confidence: 99%

Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights

Ferreira,

Vasconcelos,

Lima

et al. 2023

JPM

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Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass (CPB) may develop several biochemical changes in the microcirculation that lead to a systemic inflammatory response. Surgical incision, post-CPB reperfusion injury and blood contact with non-endothelial membranes can activate inflammatory signaling pathways that lead to the production and activation of inflammatory cells, with cytokine production and oxidative stress. This inflammatory storm can cause damage to vital organs, especially the heart, and thus lead to complications in the postoperative period. In addition to the organic pathophysiology during and after the period of exposure to extracorporeal circulation, this review addresses new perspectives for intraoperative treatment and management that may lead to a reduction in this inflammatory storm and thereby improve the prognosis and possibly reduce the mortality of these patients.

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“…Bile refux, such as chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA)-induced GIM model in vivo and in vitro, has been widely applied [10,11]. Nuclear factor erythroid-related factor 2 (NRF2), a central transcriptional regulatory factor, can be activated by oxidative stress to achieve self-protection and increase antioxidase expression [12]. Upregulated NRF2/HO-1 shows an important protective function in various infammatory diseases [13].…”

Section: Introductionmentioning

confidence: 99%

Dendrobium officinale Polysaccharides Inhibit CDCA-Induced Gastric Intestinal Metaplasia through Activating NRF2/HO-1 and Modulating HNF4α/CDX2 Signaling Pathway

Zhao,

Huang,

Wang

et al. 2023

Journal of Food Biochemistry

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Bile reflux (BR) was considered to be an independent risk factor for the development of precancerous gastric lesions and GC. Dendrobium officinale polysaccharides (DOP) show a novel potential in preventing the progress of gastric cancer. However, the specific mechanism of DOP that causes such activities remains a mystery. This study aimed to investigate the effects of DOP on chenodeoxycholic acid (CDCA)-induced gastric intestinal metaplasia and explore the underlying mechanisms. Different concentrations of DOP had no significant damage to normal GSE-1 cells and gastric intestinal metaplasia model cells by CCK-8 assay. After DOP treatment, the mRNA and protein expression of CDX2 ( p < 0.01) and HNF4α ( p < 0.01) were decreased, and HO-1 ( p < 0.05) and TFF2 ( p < 0.01) were increased. The NRF2 protein expression was slightly upregulated ( p < 0.05), and H-DOP further promoted NRF2 protein expression in the nucleus ( p < 0.05). Hence, our findings reveal that DOP could be used as a potential anti-inflammation supplement by activating NRF2/HO-1 and modulating the HNF4α/CDX2 signaling pathway to inhibit the progress of CDCA-induced gastric intestinal metaplasia.

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Nuclear factor erythroid 2-related factor 2 (Nrf2), tumor necrosis factor alpha protein (TNF-α), heme oxygenase-1 (HO-1) gene expressions during cardiopulmonary bypass

Cited by 4 publications

References 32 publications

Vasoplegic syndrome in cardiovascular surgery; evaluating effects of Sevoflurane and Glibenclamide in a porcine model

Vasoplegic syndrome in cardiovascular surgery; evaluating effects of Sevoflurane and Glibenclamide in a porcine model

Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights

Dendrobium officinale Polysaccharides Inhibit CDCA-Induced Gastric Intestinal Metaplasia through Activating NRF2/HO-1 and Modulating HNF4α/CDX2 Signaling Pathway

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