Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) as A Therapeutical Target in Type-2 Diabetes Mellitus: A Review

Hendrawati, Asri

doi:10.18585/inabj.v9i2.311

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Activation of the NRF2 pathway protects and preserves pancreatic cell mass under hyperglycemia-induced conditions of increased ROS (Baumel-Alterzon et al, 2021). It has been well demonstrated that reducing oxidative stress can be achieved by increasing NRF2 activity when there are elevated ROS (Hendrawati, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of Clitoria ternatea L. Extract on Melatonin, NRF2, and MDA Levels in Diabetic RAT

Luciana,

Damayanti,

Harliansyah

2023

kedokteran

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Oxidative stress is one of the mechanisms that causes pancreatic damage and the complications of diabetes mellitus (DM). Activating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) is important in protecting pancreatic cells from oxidative stress and inflammation. Clitoria ternatea L. (CT) flower was studied for its antioxidative effects in diabetic rats. Indeed, there has not been a lot of study on how CT impacts melatonin levels and NRF2 activity. CT flower was extracted using maceration procedures with 96% ethanol. The male Wistar rats (n=25) were randomly divided into five groups, including the control group, which received normal saline orally for 14 days. Diabetes groups received intraperitoneally (i.p.) streptozotocin (STZ) as a single dose (45 mg/kg, i.p.). Normal saline, CT (100 and 200 mg/kg), and metformin (150 mg/kg) were orally administered to diabetic rats for 14 days. The melatonin, NRF2, and malondialdehyde (MDA) levels were measured in serum. CT flower extract had no effect on melatonin levels in diabetic rats (p>0.05), but significantly increased NRF2 levels and decreased MDA levels (p<0.05). CT can activate NRF2 and reduce oxidative stress in DM, and its administration may prevent diabetes complications.

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Section: Introductionmentioning

confidence: 99%

Effect of Clitoria ternatea L. Extract on Melatonin, NRF2, and MDA Levels in Diabetic RAT

Luciana,

Damayanti,

Harliansyah

2023

kedokteran

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“…Nrf2 forms a heterodimer and interacts with Keap1 via leucine-zipper groups. (9) Under normal conditions, Nrf2 remains sequestered within the cytoplasm, maintaining low expression levels due to continuous polyubiquitination. However, exposure to various stressors induces Nrf2 expression and prevents ubiquitination.…”

Section: Introductionmentioning

confidence: 99%

Higher Nrf2 Level is Correlated with Metabolic Parameters in Type 2 Diabetes Mellitus

Triana,

Sukmawati,

Syamsunarno

et al. 2023

Indones Biomed J

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BACKGROUND: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder associated with oxidative stress and chronic inflammation. Understanding the regulatory mechanisms related to the role of nuclear factor erythroid 2 (Nrf2), a master regulator of cellular antioxidant defenses, in individuals with T2DM, is essential. Therefore, in-depth investigation regarding the associations between Nrf2 levels, and metabolic parameters, such as waist circumference, fasting glucose levels, HbA1C, and serum inflammatory markers expressions is needed to elucidate the mechanisms driving T2DM and its metabolic disturbances.METHODS: This was a cross-sectional study including 90 T2DM and 25 healthy subjects. Nrf2 level; serum inflammatory markers levels, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, interferon (IFN)-α2, IFN-g, monocyte chemoattractant protein (MCP)-1, IL-10, IL-12p70, IL-17A, IL-18 and IL-23; as well as waist circumference; fasting glucose levels; and HbA1C were measured. Nrf2 concentrations in peripheral blood mononuclear cells were determined using enzyme-linked immunosorbent assay (ELISA), while serum inflammatory markers concentrations were quantified with flowcytometry.RESULTS: Nrf2, TNF-α, and IL-17A levels were significantly higher in the T2DM group, while IL-1β, IFN-α 2, IL-10, IL-12p70, and IL-23 levels were elevated in healthy controls Nrf2 exhibited positive correlations with waist circumference, fasting glucose, HbA1C, and TNF-α. Conversely, an inverse correlation of Nrf2 was observed with IL-1β, IL-12p70 and IL-17A.CONCLUSION: Correlations between Nrf2 and metabolic clinical parameters suggest its role in regulating glucose metabolism and adiposity. Elevated Nrf2 levels observed in T2DM patients may present novel therapeutic avenues for enhancing endogenous antioxidant defenses.KEYWORDS: type 2 diabetes mellitus, Nrf2, oxidative stress, inflammation, metabolic regulation, therapeutic strategies

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(2S)-5,6,7,3′,4′-pentamethoxyflavanone, a citrus polymethoxyflavone ameliorates arsenic- and cigarette smoke extract-induced cytotoxicity via activating Nrf2-mediated defense system

Zhou

et al. 2019

Journal of Functional Foods

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Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) as A Therapeutical Target in Type-2 Diabetes Mellitus: A Review

Cited by 3 publications

References 14 publications

Effect of Clitoria ternatea L. Extract on Melatonin, NRF2, and MDA Levels in Diabetic RAT

Effect of Clitoria ternatea L. Extract on Melatonin, NRF2, and MDA Levels in Diabetic RAT

Higher Nrf2 Level is Correlated with Metabolic Parameters in Type 2 Diabetes Mellitus

(2S)-5,6,7,3′,4′-pentamethoxyflavanone, a citrus polymethoxyflavone ameliorates arsenic- and cigarette smoke extract-induced cytotoxicity via activating Nrf2-mediated defense system

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