Nuclear endonuclease G controls cell proliferation in ovarian cancer

Choi, Ye Na; Seo, Tae Woong; Lee, Yui Taek; Jeong, Dar Heum; Yoo, Soon Ji

doi:10.1002/2211-5463.13572

Cited by 2 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IFI27 may be related to platinum resistance of OC ( 47 ). Endonuclease G (ENDOG) and BAG1 promote OC cell proliferation ( 48 ) by regulating EGF signaling pathway and enhancing anoikis resistance ( 49 ). Furthermore, the roles of LRP1, RANBP9 , SERPINB1 , and CASP2 genes in OC have not been reported in previous studies, which need to be explored.…”

Section: Discussionmentioning

confidence: 99%

A signature based on anoikis-related genes for the evaluation of prognosis, immunoinfiltration, mutation, and therapeutic response in ovarian cancer

Duan

2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundOvarian cancer (OC) is a highly lethal and aggressive gynecologic cancer, with an overall survival rate that has shown little improvement over the decades. Robust models are urgently needed to distinguish high-risk cases and predict reliable treatment options for OC. Although anoikis-related genes (ARGs) have been reported to contribute to tumor growth and metastasis, their prognostic value in OC remains unknown. The purpose of this study was to construct an ARG pair (ARGP)-based prognostic signature for patients with OC and elucidate the potential mechanism underlying the involvement of ARGs in OC progression.MethodsThe RNA-sequencing and clinical information data of OC patients were obtained from The Center Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. A novel algorithm based on pairwise comparison was utilized to select ARGPs, followed by the Least Absolute Shrinkage and Selection Operator Cox analysis to construct a prognostic signature. The predictive ability of the model was validated using an external dataset, a receiver operating characteristic curve, and stratification analysis. The immune microenvironment and the proportion of immune cells were analyzed in high- and low-risk OC cases using seven algorithms. Gene set enrichment analysis and weighted gene co-expression network analysis were performed to investigate the potential mechanisms of ARGs in OC occurrence and prognosis.ResultsThe 19-ARGP signature was identified as an important prognostic predictor for 1-, 2-, and 3-year overall survival of patients with OC. Gene function enrichment analysis showed that the high-risk group was characterized by the infiltration of immunosuppressive cells and the enrichment of adherence-related signaling pathway, suggesting that ARGs were involved in OC progression by mediating immune escape and tumor metastasis.ConclusionWe constructed a reliable ARGP prognostic signature of OC, and our findings suggested that ARGs exerted a vital interplay in OC immune microenvironment and therapeutic response. These insights provided valuable information regarding the molecular mechanisms underlying this disease and potential targeted therapies.

show abstract

Section: Discussionmentioning

confidence: 99%

A signature based on anoikis-related genes for the evaluation of prognosis, immunoinfiltration, mutation, and therapeutic response in ovarian cancer

Duan

2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Further, they constitute another link between protein-quality control, UPRs, and mitochondrial responses to stress. In contrast, ENDOG has been reported to perform a protective role in the cell nuclei of ovarian cancer (OC) cells, which, it has been suggested, involve its interaction with Aurora B [ 162 ]. In OC cells, the nuclear location of ENDOG requires the activity of cIAP1 E3-ligase and elevated ROS levels.…”

Section: From Crosstalk To Integral Signallingmentioning

confidence: 99%

Mitochondrial Factors in the Cell Nucleus

González-Arzola,

Díaz-Quintana

2023

IJMS

View full text Add to dashboard Cite

The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene transfer from the original proteobacterium to the host nucleus. Thus, mitochondrial performance relies on a mosaic of nuclear gene products from a variety of genomes. The concerted regulation of their synthesis is necessary for metabolic housekeeping and stress response. This governance involves crosstalk between mitochondrial, cytoplasmic, and nuclear factors. While anterograde and retrograde regulation preserve mitochondrial homeostasis, the mitochondria can modulate a wide set of nuclear genes in response to an extensive variety of conditions, whose response mechanisms often merge. In this review, we summarise how mitochondrial metabolites and proteins—encoded either in the nucleus or in the organelle—target the cell nucleus and exert different actions modulating gene expression and the chromatin state, or even causing DNA fragmentation in response to common stress conditions, such as hypoxia, oxidative stress, unfolded protein stress, and DNA damage.

show abstract

Nuclear endonuclease G controls cell proliferation in ovarian cancer

Cited by 2 publications

References 43 publications

A signature based on anoikis-related genes for the evaluation of prognosis, immunoinfiltration, mutation, and therapeutic response in ovarian cancer

A signature based on anoikis-related genes for the evaluation of prognosis, immunoinfiltration, mutation, and therapeutic response in ovarian cancer

Mitochondrial Factors in the Cell Nucleus

Contact Info

Product

Resources

About