2011
DOI: 10.1007/s00360-011-0635-6
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Nuclear DNA content variation associated with muscle fiber hypertrophic growth in fishes

Abstract: Muscle fiber hypertrophic growth can lead to an increase in the myonuclear domain (MND), leading to greater diffusion distances within the cytoplasmic volume that each nucleus services. We tested the hypothesis that hypertrophic growth in the white muscle of fishes was associated with increases in the mean DNA content of nuclei, which may be a strategy to offset increasing diffusion constraints. DAPI-stained chicken erythrocytes standards and image analysis were used to estimate nuclear DNA content in erythroc… Show more

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Cited by 22 publications
(28 citation statements)
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“…However, in our data, number of nuclei did not increase proportionally to fiber size as evidenced by the fact that MND increased significantly with fiber diameter. This finding is consistent with an increase in the MND of white muscle of fishes as a result of an increase in muscle fiber hypertrophic growth (Jimenez & Kinsey, ).…”
Section: Discussionsupporting
confidence: 86%
See 1 more Smart Citation
“…However, in our data, number of nuclei did not increase proportionally to fiber size as evidenced by the fact that MND increased significantly with fiber diameter. This finding is consistent with an increase in the MND of white muscle of fishes as a result of an increase in muscle fiber hypertrophic growth (Jimenez & Kinsey, ).…”
Section: Discussionsupporting
confidence: 86%
“…Because muscle is a postmitotic tissue, to grow hypertrophically, new nuclei must be drawn into the fiber itself from a population of stem‐like cells, termed satellite cells, which can be found in the basement membrane of each muscle fiber, and which are limited in number throughout the lifespan of an animal (Jimenez & Kinsey, ). Myonuclear domain (MND) is defined as the amount of cytoplasm within a muscle fiber that each nucleus is responsible for servicing (Qaisar & Larsson, ).…”
Section: Introductionmentioning
confidence: 99%
“…(); 33, Henderson (); 34, Henke & Pohley (); 35, Itono et al . (); 36, Jimenez & Kinsey (); 37, Jimenez et al . (); 38, Jost & Mameli (); 39, Kiknadze & Istomina (); 40, Kooman & Nair (); 41, Korpelainen et al .…”
Section: Where Does Endopolyploidy Occur?mentioning
confidence: 99%
“…The optical thickness was 1 μm with an estimated nuclear length of 9.0 μm, which was found to be the average nuclear length of 17 teleosts in a study from our lab by Jimenez et al (2012; nuclear length data unpublished).…”
Section: Methodsmentioning
confidence: 65%
“…This leads to multinucleated fibers where each nucleus serves a volume of cell known as the myonuclear domain (MND) (Landing et al 1974; Hall and Ralston 1989; Jimenez et al 2012), and it is generally accepted that myonuclear content increases during hypertrophy (Enesco and Puddy 1964; Adams et al 1998; Roy et al 1999; Bruusgaard et al 2010; van der Meer et al 2011; Jimenez et al 2012). Changes in myonuclear content have been shown to be influenced by both mechanical loading (McCall et al 1998; Adams et al 1999; Roy et al 1999; Bruusgaard et al 2010) and neural stimulation (Ohira 1989; Schmalbruch et al 2000; Kawano et al 2007; van der Meer et al 2011), suggesting that exercise can alter satellite cell fusion.…”
Section: Introductionmentioning
confidence: 99%