Nuclear Dishevelled: An enigmatic role in governing cell fate and Wnt signaling

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

“… 143 Increasing evidence indicates that nuclear Dvl protein is critical for β-catenin and TCF factors to form a complex. 149 Dvl has been shown to interact with many other transcriptional factors including FOXK1/2, TAZ, and HIPK1, as well as gene promoters such as CYP19A1. 149 Furthermore, Dvl1 was shown to interact with EZH2 while Dvl3 interacts with chromatin-modifying enzymes such as KMT2D in cancer cells.…”

“… 149 Dvl has been shown to interact with many other transcriptional factors including FOXK1/2, TAZ, and HIPK1, as well as gene promoters such as CYP19A1. 149 Furthermore, Dvl1 was shown to interact with EZH2 while Dvl3 interacts with chromatin-modifying enzymes such as KMT2D in cancer cells. In addition, Dvl proteins are extensively modified post-translationally by phosphorylation, lysine acetylation, and methylation, as well as ubiquitination, although the functional roles of Dvl post-translational modifications remain to be fully investigated.…”

Potential effects of biomaterials on macrophage function and their signalling pathways

“…Review leads to β-catenin accumulation and its subsequent nuclear translocation, 156,157 resulting in coactivation of the transcription factors T-cell factor (TCF) and lymphoid enhancerbinding factor (LEF). 158,159 In a study, the effects of Wnt signalling on the response of macrophages to smooth, rough and rough-hydrophilic Ti surfaces were investigated through pharmacological and genetic analyses.…”

“…154,155 Frizzled (FZD) and lipoprotein receptor-related protein (LRP) 5/6 function as co-receptors in the presence of the canonical Wnt ligand, facilitating ligand recognition. This recognition leads to β-catenin accumulation and its subsequent nuclear translocation, 156,157 resulting in coactivation of the transcription factors T-cell factor (TCF) and lymphoid enhancer-binding factor (LEF). 158,159…”

DVL1variants and C-terminal deletions have differential effects on craniofacial development and WNT signaling

“…The central PDZ domain participates in both pathways and binds to FZD receptors (Wong et al, 2003). In addition, structure-function studies have shown that the conserved DIX, PDZ, DEP domains are essential for WNT signal transduction (Boligala et al, 2022; Gan et al, 2008; Itoh et al, 2005; Kishida et al, 1999; Qi et al, 2017; Rothbacher et al, 2000; Sharma et al, 2018; Wallingford and Habas, 2005; Weitzman, 2005). The three functional domains of DVL mediate interactions with more than 50 binding partners leading to different signaling outcomes (Sharma et al, 2018).…”