Nuclear Data Sheets for A=155

Nica, N.

doi:10.1016/j.nds.2019.100523

Cited by 17 publications

(21 citation statements)

References 261 publications

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“…The γ-ray spectrum obtained showed the γ-lines of terbium-155 together with those of terbium-156, terbium-154, terbium-154m and terbium-154m2 [Additional file 1 : Table S5–S6 and Fig. S6, (Nica 2019 ; Reich 2009 , Reich 2012 )]. While terbium-156 has a half-life (T 1/2 = 5.3 d) similar to terbium-155, the other radionuclidic impurities terbium-154, terbium-154m and terbium-154m2 are short-lived terbium isotopes with 21.…”

Section: Resultsmentioning

confidence: 99%

“…While terbium-156 has a half-life (T 1/2 = 5.3 d) similar to terbium-155, the other radionuclidic impurities terbium-154, terbium-154m and terbium-154m2 are short-lived terbium isotopes with 21. 5 h, 9.4 h and 22.7 h half-lives, respectively [Additional file 1 : Table S5, (Nica 2019 ; Reich 2009 , Reich 2012 )]. In particular, the measurements took place after each separation, approximately 2 days after EOB (Additional file 1 : Table S6).…”

Section: Resultsmentioning

confidence: 99%

“…Our group is investigating the emerging role of novel promising radionuclides for theragnostics (Domnanich et al 2016 ; Gracheva et al 2019 ; van der Meulen et al 2015 , 2020b ; Müller et al 2012 ). Among these radionuclides, terbium-155 is of high interest because it is a radiolanthanide that emits γ-rays of energies suitable for SPECT [Eγ = 87 keV (32%) 105 keV (25%)] (Nica 2019 ). Terbium-155 decays with a half-life of 5.32 days, which can allow the study of pre-therapeutic dosimetry and tumor visualization at later time points after administration (Müller et al 2014a ).…”

Section: Introductionmentioning

confidence: 99%

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Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

Favaretto

Talip

Borgna

et al. 2021

EJNMMI radiopharm. chem.

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Background Terbium-155 [T1/2 = 5.32 d, Eγ = 87 keV (32%) 105 keV (25%)] is an interesting radionuclide suitable for single photon emission computed tomography (SPECT) imaging with potential application in the diagnosis of oncological disease. It shows similar decay characteristics to the clinically established indium-111 and would be a useful substitute for the diagnosis and prospective dosimetry with biomolecules that are afterwards labeled with therapeutic radiolanthanides and pseudo-radiolanthanides, such as lutetium-177 and yttrium-90. Moreover, terbium-155 could form part of the perfect “matched pair” with the therapeutic radionuclide terbium-161, making the concept of true radiotheragnostics a reality. The aim of this study was the investigation of the production of terbium-155 via the 155Gd(p,n)155Tb and 156Gd(p,2n)155Tb nuclear reactions and its subsequent purification, in order to obtain a final product in quantity and quality sufficient for preclinical application. The 156Gd(p,2n)155Tb nuclear reaction was performed with 72 MeV protons (degraded to ~ 23 MeV), while the 155Gd(p,n)155Tb reaction was degraded further to ~ 10 MeV, as well as performed at an 18 MeV medical cyclotron, to demonstrate its feasibility of production. Result The 156Gd(p,2n)155Tb nuclear reaction demonstrated higher production yields of up to 1.7 GBq, however, lower radionuclidic purity when compared to the final product (~ 200 MBq) of the 155Gd(p,n)155Tb nuclear reaction. In particular, other radioisotopes of terbium were produced as side products. The radiochemical purification of terbium-155 from the target material was developed to provide up to 1.0 GBq product in a small volume (~ 1 mL 0.05 M HCl), suitable for radiolabeling purposes. The high chemical purity of terbium-155 was proven by radiolabeling experiments at molar activities up to 100 MBq/nmol. SPECT/CT experiments were performed in tumor-bearing mice using [155Tb]Tb-DOTATOC. Conclusion This study demonstrated two possible production routes for high activities of terbium-155 using a cyclotron, indicating that the radionuclide is more accessible than the exclusive mass-separated method previously demonstrated. The developed radiochemical purification of terbium-155 from the target material yielded [155Tb]TbCl3 in high chemical purity. As a result, initial cell uptake investigations, as well as SPECT/CT in vivo studies with [155Tb]Tb-DOTATOC, were successfully performed, indicating that the chemical separation produced a product with suitable quality for preclinical studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

Favaretto

Talip

Borgna

et al. 2021

EJNMMI radiopharm. chem.

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“…Articles report data and evaluate data of a specific type. For example, since 1975 it has published at least six articles with the same title, "Nuclear data sheets for A=155", with the latest reporting, "This work represents an update of the previous evaluation of the nuclear data on the A=155 nuclides" (Nica, 2019). This could be viewed as a traditional journal with an emphasis on data or a data journal with an emphasis on data evaluation.…”

Section: Introductionmentioning

confidence: 99%

Data in Brief: Can a mega-journal for data be useful?

Thelwall

2020

Scientometrics

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As part of the current move towards open science, there is increasing pressure for scientists to share their research data. In support of this, several journals only publish descriptions of data generated from research: data papers. It is not clear whether this service encourages data reuse, however. This article assesses the prevalence and impact of the largest such journal, Data in Brief, comparing it with 24 other general or specialist data journals. The results show that Data in Brief became the largest data journal in 2016 and that its papers attracted over five Mendeley readers each, within a year of publication, as well as a nontrivial amount of citations. Its papers have been cited for relevance or facts contained in them in addition to acknowledging the reuse of associated datasets in about 1% of cases. Some papers describe electronic dataset whereas other papers embedded the tables or images that formed the shared data. Overall, the journal seems to make a positive contribution to science by enabling access to multiple types of data, even though its papers rarely lead to data reuse.

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“…As can be seen in this Figure, the stronger transition is the one of 226.9 keV with intensity I=68.7 %. The remaining ones have much lower intensities [46]. • the 165 Ho(n,2n) 164 Ho reaction As has been mentioned, the (n,2n) channel of the 165 Ho isotope populates two states of the product-nucleus 164 Ho: the ground state with spin J π = 1 + and an isomeric state, excited at 139.8 keV, with spin J π = 6 − .…”

Section: Activation Techniquementioning

confidence: 99%

Study of neutron induced reactions in rare earth isotopes

Georgali¹,

Γεωργαλή²

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Στα πλαίσια της παρούσας εργασίας μελετήθηκε η αντίδραση (n,2n) για τα ισότοπα σπάνιων γαιών: 162Er, 156Dy και 165Ho. Συγκεκριμένα, για το 165Ho οι ενεργές διατομές τροφοδοσίας της βασικής και της ισομερούς κατάστασης του 164Ho μετρήθηκαν ανεξάρτητα. Οι ενεργές διατομές των αντιδράσεων μετρήθηκαν μέσω της τεχνικής της ενεργοποίησης σε σχέση με τις αντιδράσεις αναφοράς 197Au(n,2n)196Au, 27Al(n,α)24Na και 93Nb(n,2n)92mNb. Οι ημι-μονοενεργειακές δέσμες νετρονίων παρήχθησαν μέσω των αντιδράσεων 2H(d,n)3He (DD) και 3H(d,n)4He (DT), όπου οι δέσμες δευτερίων επιταχύνθηκαν από τον 5.5 MV Tandem Van de Graaff επιταχυντή του Ινστιτούτου Πυρηνικής και Σωματιδιακής Φυσικής του Ε.Κ.Ε.Φ.Ε. «Δημόκριτος», Αθήνα, Ελλάδα. Μετά το τέλος των ακτινοβολήσεων, η επαγόμενη ενεργότητα στα δείγματα μετρήθηκε μέσω φασματοσκοπίας ακτίνων-γ χρησιμοποιώντας ανιχνευτές γερμανίου υπερ-υψηλής καθαρότητας (HPGe). Κατά την ανάλυση των πειραματικών δεδομένων, το λογισμικό GEANT4 χρησιμοποιήθηκε εκτενώς για την προσομοίωση των HPGe ανιχνευτών. Οι κώδικες των ανιχνευτών χρησιμοποιήθηκαν για τον προσδιορισμό της απόδοσης των ανιχνευτών, καθώς και για την αναπαραγωγή των πειραματικών φασμάτων. Επιπλέον, ο κώδικας GEANT4 χρησιμοποιήθηκε για τον υπολογισμό της κατανομής της ενέργειας των δεσμών νετρονίων που παράγονται απο τον 5.5 MV Tandem επιταχυντή στο Ε.Κ.Ε.Φ.Ε. «Δημόκριτος» μέσω των αντιδράσεων DD και DT. Τα πειραματικά δεδομένα που προέκυψαν από την παρούσα μελέτη συγκρίθηκαν με προηγούμενες μετρήσεις της βιβλιογραφίας, καθώς και με θεωρητικούς υπολογισμούς με βάση τον κώδικα TALYS (v. 1.95).

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Nuclear Data Sheets for A=155

Cited by 17 publications

References 261 publications

Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

Data in Brief: Can a mega-journal for data be useful?

Study of neutron induced reactions in rare earth isotopes

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