Nuclear DAMPs in Hepatic Injury and Inflammation

Kang, Rui; Tang, Daolin

doi:10.1007/978-3-319-58106-4_7

Cited by 1 publication

(1 citation statement)

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“…DAMPs typically originate from an intracellular source (cytoplasm, mitochondria, and nucleus) and are associated with hepatocellular injury during reperfusion [86][87][88][89]. More recently, attention has been drawn to DAMPs of nuclear origin that have a significant potential to exacerbate injury during liver IRI.…”

Section: Damage-associated Molecular Patterns (Damps)mentioning

confidence: 99%

Steatotic Donor Transplant Livers: Preservation Strategies to Mitigate against Ischaemia-Reperfusion Injury

Abbas,

Ceresa,

Pollok

2024

IJMS

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Liver transplantation (LT) is the only definitive treatment for end-stage liver disease, yet the UK has seen a 400% increase in liver disease-related deaths since 1970, constrained further by a critical shortage of donor organs. This shortfall has necessitated the use of extended criteria donor organs, including those with evidence of steatosis. The impact of hepatic steatosis (HS) on graft viability remains a concern, particularly for donor livers with moderate to severe steatosis which are highly sensitive to the process of ischaemia-reperfusion injury (IRI) and static cold storage (SCS) leading to poor post-transplantation outcomes. This review explores the pathophysiological predisposition of steatotic livers to IRI, the limitations of SCS, and alternative preservation strategies, including novel organ preservation solutions (OPS) and normothermic machine perfusion (NMP), to mitigate IRI and improve outcomes for steatotic donor livers. By addressing these challenges, the liver transplant community can enhance the utilisation of steatotic donor livers which is crucial in the context of the global obesity crisis and the growing need to expand the donor pool.

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Section: Damage-associated Molecular Patterns (Damps)mentioning

confidence: 99%