2015
DOI: 10.1007/s00395-015-0494-5
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Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction

Abstract: Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, functions as a transcription factor to promote NOX2 expression following myocardial IR in a phosphorylation-dependent manner. We examined the phosphorylation status of nuclear MYL2 (p-MYL2) in a rat mo… Show more

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Cited by 30 publications
(20 citation statements)
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“…Oxidative stress is usually caused by the overproduction of reactive oxygen species (ROS) and NADPH oxidases (NOX), particularly NOX2 and NOX4, which are considered as the major source of ROS in cardiovascular system. Studies from other labs and ours have repeatedly demonstrated that NOX-derived ROS contributes greatly to myocardial/cerebral ischemic injury [8][9][10], endothelial dysfunction [11,12], and vascular remodeling [13,14]. There is growing evidence that NOX is activated in animals or humans with PAH, indicating that NOX-derived ROS may contribute to the development of PAH [15][16][17].…”
Section: Introductionmentioning
confidence: 83%
“…Oxidative stress is usually caused by the overproduction of reactive oxygen species (ROS) and NADPH oxidases (NOX), particularly NOX2 and NOX4, which are considered as the major source of ROS in cardiovascular system. Studies from other labs and ours have repeatedly demonstrated that NOX-derived ROS contributes greatly to myocardial/cerebral ischemic injury [8][9][10], endothelial dysfunction [11,12], and vascular remodeling [13,14]. There is growing evidence that NOX is activated in animals or humans with PAH, indicating that NOX-derived ROS may contribute to the development of PAH [15][16][17].…”
Section: Introductionmentioning
confidence: 83%
“…A previous study identified that NOX2 and NOX4 are the major NOXs responsible for brain tissue ROS production in a rat ischemic stroke model (6). Numerous factors are reported to be associated with the regulation of NOX expression, including the transcription factor, nuclear factor (NF)-κB and myosin light chain (7). However, the detailed mechanism by which NOX expression is regulated has not yet been fully elucidated.…”
Section: Introductionmentioning
confidence: 99%
“…However, our previous studies found that NOX2 and NOX4 were the major subtypes responsible for brain tissue ROS production in a rat model of ischemic stroke [8]. Presently, many factors have been reported to be involved in the regulation of NOX expression, including transcription factor NF-κB and myosin light chain [9]. However, the detailed mechanism underlying NOX expression regulation is not fully elucidated.…”
Section: Introductionmentioning
confidence: 99%