Nuclear Calcium Signaling in Plants

Charpentier, Myriam; Oldroyd, Giles

doi:10.1104/pp.113.220863

Cited by 71 publications

(39 citation statements)

References 94 publications

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“…In the latter case, Ca 2+ may permeate from the cytosol into the nucleus, or it can be released by different transporters from Ca 2+ stores in the lumen of the nuclear envelope contiguous with the endoplasmic reticulum. Many mechanisms account for nuclear calcium signaling and calcium-regulated transcription in plants (Galon et al, 2010;Charpentier and Oldroyd, 2013). Recently, a nuclear calcium-sensing pathway required for the salt stress response has been reported in Arabidopsis, and it is well known that calcium/ CaM binding transcription activators (CAMTAs) mediate abiotic stress responses (Galon et al, 2010;Guan et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of PYR/PYL/RCAR Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis

et al. 2014

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Section: Discussionmentioning

confidence: 99%

C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of PYR/PYL/RCAR Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis

et al. 2014

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“…Thus, the IQD family may provide an assortment of versatile platform proteins that facilitate and specify CaM/CML dynamics during Ca 2+ signaling at the cell periphery, on the cytoskeleton, and in the cell nucleus. Interactions of IQDs and CaM/ CMLs in the nucleus may integrate nuclear calcium signaling (Charpentier and Oldroyd, 2013) and regulate a proposed function of select IQD proteins during mRNA maturation, export, and cytoplasmic transport Bürstenbinder et al, 2013). These processes share nucleocytoplasmic protein factors and allow for efficient fine-tuning of protein targeting and activity (Marchand et al, 2012;Shahbabian and Chartrand, 2012).…”

Section: Discussionmentioning

confidence: 99%

The IQD Family of Calmodulin-Binding Proteins Links Calcium Signaling to Microtubules, Membrane Subdomains, and the Nucleus

et al. 2017

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ORCID IDs: 0000-0002-3493-4800 (K.B.); 0000-0002-7146-043X (B.M.).Calcium (Ca 2+ ) signaling and dynamic reorganization of the cytoskeleton are essential processes for the coordination and control of plant cell shape and cell growth. Calmodulin (CaM) and closely related calmodulin-like (CML) polypeptides are principal sensors of Ca 2+ signals. CaM/CMLs decode and relay information encrypted by the second messenger via differential interactions with a wide spectrum of targets to modulate their diverse biochemical activities. The plant-specific IQ67 DOMAIN (IQD) family emerged as possibly the largest class of CaM-interacting proteins with undefined molecular functions and biological roles. Here, we show that the 33 members of the IQD family in Arabidopsis (Arabidopsis thaliana) differentially localize, using green fluorescent protein (GFP)-tagged proteins, to multiple and distinct subcellular sites, including microtubule (MT) arrays, plasma membrane subdomains, and nuclear compartments. Intriguingly, the various IQD-specific localization patterns coincide with the subcellular patterns of IQD-dependent recruitment of CaM, suggesting that the diverse IQD members sequester Ca 2+ -CaM signaling modules to specific subcellular sites for precise regulation of Ca 2+ -dependent processes. Because MT localization is a hallmark of most IQD family members, we quantitatively analyzed GFP-labeled MT arrays in Nicotiana benthamiana cells transiently expressing GFP-IQD fusions and observed IQD-specific MT patterns, which point to a role of IQDs in MT organization and dynamics. Indeed, stable overexpression of select IQD proteins in Arabidopsis altered cellular MT orientation, cell shape, and organ morphology. Because IQDs share biochemical properties with scaffold proteins, we propose that IQD families provide an assortment of platform proteins for integrating CaM-dependent Ca 2+ signaling at multiple cellular sites to regulate cell function, shape, and growth.

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“…The perception of Nod factors leads to depolarization of cell membranes and changes in ion fluxes. These changes include oscillations in calcium concentrations called "calcium spiking" in the nuclei of epidermal root hair cells, which appear to drive changes in gene expression associated with nodule development and infection (Figure 3;Charpentier and Oldroyd, 2013). This is followed by deformation of root hairs, early nodulin gene expression, and, subsequently, the formation of nodule primordia.…”

Section: Nod Factor Signaling and The Common Symbiotic Pathwaymentioning

confidence: 99%

Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation

Roy¹,

Liu²,

Nandety³

et al. 2019

Plant Cell

469

484

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Since 1999, various forward-and reverse-genetic approaches have uncovered nearly 200 genes required for symbiotic nitrogen fixation (SNF) in legumes. These discoveries advanced our understanding of the evolution of SNF in plants and its relationship to other beneficial endosymbioses, signaling between plants and microbes, the control of microbial infection of plant cells, the control of plant cell division leading to nodule development, autoregulation of nodulation, intracellular accommodation of bacteria, nodule oxygen homeostasis, the control of bacteroid differentiation, metabolism and transport supporting symbiosis, and the control of nodule senescence. This review catalogs and contextualizes all of the plant genes currently known to be required for SNF in two model legume species, Medicago truncatula and Lotus japonicus, and two crop species, Glycine max (soybean) and Phaseolus vulgaris (common bean). We also briefly consider the future of SNF genetics in the era of pan-genomics and genome editing.

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Nuclear Calcium Signaling in Plants

Abstract: Plant cell nuclei can generate calcium responses to a variety of inputs, tantamount among them the response to signaling molecules from symbiotic microorganisms.

Cited by 71 publications

References 94 publications

C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of PYR/PYL/RCAR Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis

C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of PYR/PYL/RCAR Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis

The IQD Family of Calmodulin-Binding Proteins Links Calcium Signaling to Microtubules, Membrane Subdomains, and the Nucleus

Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation

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