Nuclear blebs are associated with destabilized chromatin packing domains
Emily M. Pujadas Liwag,
Nicolas Acosta,
Luay Matthew Almassalha
et al.
Abstract:Disrupted nuclear shape is associated with multiple pathological processes including premature aging disorders, cancer-relevant chromosomal rearrangements, and DNA damage. Nuclear blebs (i.e., herniations of the nuclear envelope) have been induced by (1) nuclear compression, (2) nuclear migration (e.g., cancer metastasis), (3) actin contraction, (4) lamin mutation or depletion, and (5) heterochromatin enzyme inhibition. Recent work has shown that chromatin transformation is a hallmark of bleb formation, but th… Show more
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