Nuclear and membrane receptor-mediated signalling pathways modulate polyamine biosynthesis and interconversion

Grzelakowska-Sztabert, Barbara; Dudkowska, Magdalena; Manteuffel-Cymborowska, Małgorzata

doi:10.1042/bst0350386

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…First, stress differentially modulates fear conditioning in men and women; stress increases salivary cortisol and enhances fear conditioning in males, whereas it seems to interfere with the development of fear conditioning response in women [Jackson et al, 2006]. Moreover, gonadal factors modulate the hypothalamic‐pituitary‐adrenal (HPA) axis [Bastida et al, 2007] and SSAT‐1 activity is down‐regulated by testosterone [Levillain et al, 2003; Grzelakowska‐Sztabert et al, 2007].…”

Section: Sample Descriptivementioning

confidence: 99%

Positive association between SAT‐1 −1415T/C polymorphism and anxiety

Vaquero-Lorenzo

Bermudo-Soriano²,

Perez‐Rodriguez

et al. 2008

American J of Med Genetics Pt B

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Limbic glutamatergic neurotransmission plays a pivotal role in the pathogenesis of anxiety disorders. Polyamines modulate the activity of several ionotropic glutamate receptors and have been involved in the regulation of fear-conditioning response. Spermidine/spermine N1-acetyltransferase (SSAT-1) is the main enzyme regulating polyamine catabolism. The aim of the present study was to examine the association between anxiety disorders and the -1415T/C (rs1960264) single nucleotide polymorphism (SNP) of the gene (SAT1) coding for SSAT-1. A case-control design was used in order to compare the genotypes for the -1415T/C (rs1960264) SNP between anxiety patients (n = 218), other non-anxiety psychiatric patients (n = 362), and healthy controls (n = 251). DSM-IV diagnoses were provided using MINI 4.4. Genomic DNA was extracted from peripheral blood samples collected from participants. In males, there was a significant difference in the distribution of the two genotypes (T and C) for the SAT-1 -1415T/C SNP between anxiety patients, non-anxiety psychiatric controls, and healthy controls. The T genotype was significantly more frequent in males suffering from anxiety disorders than in male psychiatric controls and healthy controls. This is the first study linking polymorphic variants of genes involved in polyamine metabolism with anxiety disorders.

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Section: Sample Descriptivementioning

confidence: 99%

Positive association between SAT‐1 −1415T/C polymorphism and anxiety

Vaquero-Lorenzo

Bermudo-Soriano²,

Perez‐Rodriguez

et al. 2008

American J of Med Genetics Pt B

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“…Based on the findings that nuclear and membrane receptor-mediated signalling pathways modulate polyamine biosynthesis and interconversion 33 , we first tested whether FATS interacts with three nuclear receptors, androgen receptor (AR) 34 , oestrogen receptor (ER, two isoforms, alpha and beta) 35 and Glu-cocorticoid receptor (GR) 36 , which are reported members of the nuclear receptor family. Consistent with our hypothesis, FATS was confirmed to interact with ERβ in NSCLC cells (Fig.…”

Section: Fats Erβ and Odc Bind To Each Othermentioning

confidence: 99%

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

Qiu

Wang

et al. 2020

Cell Death Dis

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Polyamine biosynthesis is an essential metabolic pathway for cell growth and differentiation in non-small-cell lung cancer (NSCLC). Fragile-site associated tumour suppressor (FATS) is a novel gene involved in cancer. The results of our previous study showed that FATS-mediated polyubiquitination of p53 promotes the activation of p53 in response to DNA damage; however, little is known about the role of FATS in metabolic reprogramming in NSCLC. In the present study, FATS was observed to be significantly downregulated in NSCLC tissues compared with paired adjacent normal tissues and was associated with the survival of NSCLC patients. We further showed that the presence of the tumour suppressor FATS in NSCLC cells led to apoptosis by inducing pro-death autophagy. In addition, FATS was shown to function as a suppressor of polyamine biosynthesis by inhibiting ornithine decarboxylase (ODC) at the protein and mRNA levels, which was partially dependent on oestrogen receptor (ER). Furthermore, FATS was observed to bind to ERβ and translocate to the cytosol, leading to ODC degradation. The findings of our study demonstrate that FATS plays important roles in polyamine metabolism in NSCLC and provides a new perspective for NSCLC progression.

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Dietary Polyamine Intake and Polyamines Measured in Urine

Vargas

Ashbeck

Thomson

et al. 2014

Nutrition and Cancer

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Dietary polyamines have recently been associated with increased risk of pre-malignant colorectal lesions. Because polyamines are synthesized in cells and taken up from dietary sources, development of a biomarker of exposure is challenging. Excess polyamines are primarily excreted in the urine. This pilot study seeks to identify dietary correlates of excreted urinary polyamines as putative biomarkers of exposure. Dietary polyamines/other nutrients were estimated from a food frequency questionnaire (FFQ) and correlated with urinary levels of acetylated polyamines in 36 men using 24-h urine samples. Polyamines, abundant in cheese and citrus, were highly positively correlated with urinary N(8)-acetylspermidine (correlation coefficient; r = 0.37, P = 0.03), but this correlation was attenuated after adjustment for total energy intake (r = 0.07, P = 0.68). Dietary energy intake itself was positively correlated with urinary total acetylated polyamine output (r = .40, P = 0.02). In energy-adjusted analyses, folic acid and folate from food were associated with urinary N(1),N(12)-diacetylspermine (r = 0.34, P = 0.05 and r = -0.39, P = 0.02, respectively). Red meat negatively correlated with total urinary acetylated polyamines (r = -0.42, P = 0.01). Our findings suggest that energy, folate, folic acid, saturated fat, and red meat intake, as opposed to FFQ-estimated dietary polyamines, are correlated with urinary polyamines.

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Nuclear and membrane receptor-mediated signalling pathways modulate polyamine biosynthesis and interconversion

Cited by 4 publications

References 53 publications

Positive association between SAT‐1 −1415T/C polymorphism and anxiety

Positive association between SAT‐1 −1415T/C polymorphism and anxiety

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

Dietary Polyamine Intake and Polyamines Measured in Urine

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