Nuclear and cellular volumetric alterations in oral lichen planus and lichenoid lesions: A histomorphometric study.

Abstract

There is presently no line of distinction between oral lichen planus and other oral lichenoid lesions. The aim of this study is to determine using histomorphometry, the differences between these lesions. Paraffin sections from 7 normal buccal epithelium, 19 oral lichen planus (LP), 14 oral lichenoid lesions (LL) and 7 discoid lupus erythematosus-like lesions (DLE-II) were selected. The nuclear volume (VN) and cellular-volume (VCELL) of the epithelium were assessed using an image analyser. The VN and VCELL derived for both basal and spinal strata in LP and DLE-II were 2.3 times more than that of normal tissues. There was a significant difference between LP and LL (P < 0.005) and between LL and DLE-II (P < 0.001), but not between LP and DLE-II. In conclusion, there appears to be a difference between LP, LL and DLE-II and VN and VCELL may serve as potential discriminators between these groups of lesions. (J.

Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications

“…Although several molecular biologic markers have been suggested to be useful as an additional diagnostic tool in diagnosing OLP, there seems not to be enough scientific evidence yet to apply those as a ‘golden standard’(9–13). Direct immunofluorescent techniques have also been described as additional tool in the diagnostic assessment of OLP (14–20).…”

Nuclear features in oral squamous cell carcinoma: A computer-assisted microscopic study

“…Nuclear morphometry has been used for grading carcinomas of larynx, esophagus, kidney, bladder, breast, prostate and colon,[1] and to distinguish oral hyperplasias and dysplasias,[1] oral lichen planus and lichenoid lesions. [2]…”

Oral Lichenoid Lesions in HIV-HCV-Coinfected Subjects During Antiviral Therapy: 2 Cases and Review of the Literature

“…[39][40][41][42] In conclusion, our new cases, together with the previous reports of a possible association between OLP and/or OLL and anti-HCV therapy, highlight the absolute need to carefully follow-up the HIV-HCV-coinfected subjects who are about to start the anti-HCV therapy, to identify the onset of these lesions from the start. APPENDIX 1.…”