Nuciferine Relaxes Tracheal Rings via the Blockade of VDLCC and NSCC Channels

Yang, Xiaofei; Yu, Meng‐Fei; Lei, Jun; Peng, Yongbo; Zhao, Ping; Lü, Xue; Chen, Weiwei; Ma, Li-Qun; Liu, Qinghua

doi:10.1055/s-0043-118178

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…This molecule is an aporphine alkaloid of lotus leaf extract which can induce relaxation in contracted tracheal rings. It induce relaxation in tracheal rings mainly by inhibition of extracellular Ca 2+ influx through the blockade of voltage-dependent L-type Ca 2+ channels and/or nonselective cation channels, showing therapeutic effect on respiratory diseases associated with the aberrant contraction of airway smooth muscles and/or bronchospasm (23,24). In our experience the patients who underwent Protopine and Nuciferine syrup treatment, showed a better IPSS score, a better control of urgency symptoms (PPIUS) and tolerate well the pain related to the chemo-hyperthermia treatment (VAS score) compared to control group.…”

Section: Discussionmentioning

confidence: 99%

The role of Protopine associated with Nuciferine in controlling adverse events during hyperthermic intravesical chemotherapy instillations. A nutraceutical approach to control adverse event during intravesical instillations

Chiancone

Carrino

Fedelini

et al. 2020

Arch Ital Urol Androl

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Objectives: The aim of this study was to analyse the role of two alkaloid, Protopine and Nuciferine, in the prevention and the treatment of the low and mild grade adverse events related to the use of HIVEC® (Hyperthermic IntraVEsical Chemotherapy) instillations. Materials and methods: From September 2017 to September 2019, 100 patients were prospectively randomized into two groups: Group A = Protopine and Nuciferine syrup, 10 ml, once a day, for 8 weeks; Group B = placebo (flavoured coloured water), 10 ml, once a day, for 8 weeks. The primary endpoint was the evaluation of the efficacy of the therapy with Protopine and Nuciferine in controlling of the irritative symptoms. The secondary endpoint was the evaluation of the influences of the treatment on the uroflowmetric parameters. Results: The patients of Group A showed a better International Prostatic Symptoms Score (IPSS) score, a better control of urgency symptoms (PPIUS) and tolerate well the pain (VAS score). The treatment doesn’t modify Uroflow-Qmax and seems to improve the Uroflow-Voided Volume (ml) without influencing the Uroflow-Post Void Residual volume (PVR). Moreover, the treatment with Protopine and Nuciferine has been proven to be effective in the treatment of overactive bladder (OAB) symptoms. Patients’ evaluation of the two different treatments assessed with Patient Global Impression of Improvement questionnaire (PGI-I), demonstrated improvements in the Group A, while the Group B showed a lower satisfaction.Conclusions: Protopine and Nuciferine can be interesting nutraceutical compounds useful to control irritative and pain related symptoms of intravesical chemo/immunotherapy.

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Section: Discussionmentioning

confidence: 99%

The role of Protopine associated with Nuciferine in controlling adverse events during hyperthermic intravesical chemotherapy instillations. A nutraceutical approach to control adverse event during intravesical instillations

Chiancone

Carrino

Fedelini

et al. 2020

Arch Ital Urol Androl

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“…VDLCC currents were recorded as previously reported with some modifications (Yang et al, 2018; Zhang et al, 2018). Briefly, mouse ASM cells were isolated as described above.…”

Section: Methodsmentioning

confidence: 99%

Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle

Chen

Yang

et al. 2019

Front. Pharmacol.

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Diclofenac sodium (DCF) is a nonsteroidal anti-inflammatory drug (NSAID) and is widely used as an analgesic and anti-inflammatory agent. Herein, we found that DCF could relax high K + (80 mM K + )-/ACh-precontracted tracheal rings (TRs) in mice. This study aimed to elucidate the underlying mechanisms of DCF-induced relaxations. The effects of DCF on airway smooth muscle (ASM) cells were explored using multiple biophysiological techniques, such as isometric tension measurement and patch-clamping experiments. Both high K + - and ACh-evoked contraction of TRs in mice were relaxed by DCF in a dose-dependent manner. The results of isometric tension and patch-clamping experiments demonstrated that DCF-induced relaxation in ASM cells was mediated by cytosolic free Ca 2+ , which was decreased via inhibition of voltage-dependent L-type Ca 2+ channels (VDLCCs), nonselective cation channels (NSCCs), and Na +/ Ca 2+ exchange. Meanwhile, DCF also enhanced large conductance Ca 2+ activated K + (BK) channels, which led to the relaxation of ASMs. Our data demonstrated that DCF relaxed ASMs by decreasing the intracellular Ca 2+ concentration via inhibition of Ca 2+ influx and Na + /Ca 2+ exchange. Meanwhile, the enhanced BK channels also played a role in DCF-induced relaxation in ASMs. These results suggest that DCF is a potential candidate for antibronchospasmic drugs used in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease.

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“…It restores acetylcholine-induced contraction in mouse tracheal rings with intracellular Ca 2+ influx and whole-cell currents of non-selective cation channels. Thus, nuciferine may have a therapeutic effect on respiratory disorders associated with aberrant contractions of airway smooth muscles and/or bronchospasm [ 94 ].…”

Section: Potential Effect On Other Disordersmentioning

confidence: 99%

Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome

et al. 2021

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The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As a major risk factor for various diseases, metabolic syndrome has come into focus in recent years. Some natural aporphine alkaloids are very promising agents in the prevention and treatment of metabolic syndrome and its components because of their wide variety of biological activities. These natural aporphine alkaloids have protective effects on the different risk factors characterizing metabolic syndrome. In this review, we highlight the activities of bioactive aporphine alkaloids: thaliporphine, boldine, nuciferine, pronuciferine, roemerine, dicentrine, magnoflorine, anonaine, apomorphine, glaucine, predicentrine, isolaureline, xylopine, methylbulbocapnine, and crebanine. We particularly focused on their impact on metabolic syndrome and its components, including insulin resistance and type 2 diabetes mellitus, endothelial dysfunction, hypertension and cardiovascular disease, hyperlipidemia and obesity, non-alcoholic fatty liver disease, hyperuricemia and kidney damage, erectile dysfunction, central nervous system-related disorder, and intestinal microbiota dysbiosis. We also discussed the potential mechanisms of actions by aporphine alkaloids in metabolic syndrome.

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Nuciferine Relaxes Tracheal Rings via the Blockade of VDLCC and NSCC Channels

Cited by 9 publications

References 26 publications

The role of Protopine associated with Nuciferine in controlling adverse events during hyperthermic intravesical chemotherapy instillations. A nutraceutical approach to control adverse event during intravesical instillations

The role of Protopine associated with Nuciferine in controlling adverse events during hyperthermic intravesical chemotherapy instillations. A nutraceutical approach to control adverse event during intravesical instillations

Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle

Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome

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