Nuciferine attenuates lipopolysaccharide-stimulated inflammatory responses by inhibiting p38 MAPK/ATF2 signaling pathways

Kim, Sung-Min; Park, Eun-Jung; Lee, You‐Suk

doi:10.1007/s10787-022-01075-y

Cited by 18 publications

(12 citation statements)

References 46 publications

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“…An early study demonstrated that inhibition of the PGE2/EP2R and coupled cAMP–PKA–CREB signaling pathways ameliorated diabetes-associated inflammation, which was associated with acute activation of the NLRP3 inflammasome [49] . In addition, another previous study also illustrated that the activation of PGE2 signaling could attenuate the activation of macrophages induced by LPS stimulation and reduce TNF-α expression levels [50] . PGE2 and its receptor EP2 are effective at attenuating NLRP3 inflammasome activation against the LPS-induced classical activation of macrophages.…”

Section: Discussionmentioning

confidence: 90%

Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor

Huang

Lee

Sung

et al. 2023

Computational and Structural Biotechnology Journal

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Section: Discussionmentioning

confidence: 90%

Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor

Huang

Lee

Sung

et al. 2023

Computational and Structural Biotechnology Journal

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“…Nuciferine (NF), an alkaloid originally isolated from lotus ( Nelumbo nucifera Gaertn.) leaves, has therapeutic effects such as anti-obesity, antioxidant, and anti-inflammatory properties ( Kim S. M. et al, 2022 ). Axin protein levels significantly increased in NF-treated cells, but not APC or GSK-3 expression levels, while Axin, APC, or GSK-3 mRNA levels were unaffected.…”

Section: Intervention Of Natural Products On the Canonical Wnt Pathwa...mentioning

confidence: 99%

Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer

Shen,

Gao,

et al. 2023

Front. Pharmacol.

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The Wnt/β-catenin pathway is abnormally activated in most lung cancer tissues and considered to be an accelerator of carcinogenesis and lung cancer progression, which is closely related to increased morbidity rates, malignant progression, and treatment resistance. Although targeting the canonical Wnt/β-catenin pathway shows significant potential for lung cancer therapy, it still faces challenges owing to its complexity, tumor heterogeneity and wide physiological activity. Therefore, it is necessary to elucidate the role of the abnormal activation of the Wnt/β-catenin pathway in lung cancer progression. Moreover, Wnt inhibitors used in lung cancer clinical trials are expected to break existing therapeutic patterns, although their adverse effects limit the treatment window. This is the first study to summarize the research progress on various compounds, including natural products and derivatives, that target the canonical Wnt pathway in lung cancer to develop safer and more targeted drugs or alternatives. Various natural products have been found to inhibit Wnt/β-catenin in various ways, such as through upstream and downstream intervention pathways, and have shown encouraging preclinical anti-tumor efficacy. Their diversity and low toxicity make them a popular research topic, laying the foundation for further combination therapies and drug development.

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“…Nuciferine is an active chemical constituent in plants that inhibit the signalling pathways and possess anti-inflammatory activity. [52] Moreover lotus plant contains useful metabolites including steroids, [53] alkaloids, [21] glycosides, [54] triterpenoids, [55] flavonoids, [56] and polyphenols [57] that have potential biological activities alleviate the risk of disease. Moreover, the plant has extraordinary nutrition and food supplement such as protein, carbohydrate, fibres, essential and non-essential amino acids and water-soluble vitamins.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the signalling pathways p38 mitogen‐activated protein kinase (MAPK), mitogen‐activated protein kinase‐3 (MKK3) and bioactive nitric oxide, prostaglandins, and cytokines are responsible for inflammation. Nuciferine is an active chemical constituent in plants that inhibit the signalling pathways and possess anti‐inflammatory activity [52] . Moreover lotus plant contains useful metabolites including steroids, [53] alkaloids, [21] glycosides, [54] triterpenoids, [55] flavonoids, [56] and polyphenols [57] that have potential biological activities alleviate the risk of disease.…”

Section: Introductionmentioning

confidence: 99%

An Updated Review on Nelumbo Nucifera Gaertn: Chemical Composition, Nutritional Value and Pharmacological Activities

Sahu,

Sahu

et al. 2024

Chemistry & Biodiversity

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Nelumbo nucifera Gaertn is a recognised herbal plant in ancient medical sciences. Each portion of the plant leaf, flower, seed and rhizome is utilised for nutritional and medicinal purposes. The chemical compositions like phenol, alkaloids, glycoside, terpenoids and steroids have been isolated. The plant contains various nutritional values like lipids, proteins, amino acids, minerals, carbohydrates, and fatty acids. Traditional medicine confirms that the phytochemicals of plants give significant benefits to the treatment of various diseases such as leukoderma, smallpox, dysentery, haematemesis, coughing, haemorrhage, metrorrhagia, haematuria, fever, hyperlipidaemia, cholera, hepatopathy and hyperdipsia. To verify the traditional claims, researchers have conducted scientific biological in vivo and in vitro screenings, which have exhibited that the plant keeps various notable pharmacological activities such as anticancer, hepatoprotective, antioxidant, antiviral, hypolipidemic, anti‐obesity, antipyretic, hypoglycaemic, antifungal, anti‐inflammatory and antibacterial activities. This review, summaries the nutritional composition, chemical constituents and biological activities substantiated by the researchers done in vivo and in vitro.

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Nuciferine attenuates lipopolysaccharide-stimulated inflammatory responses by inhibiting p38 MAPK/ATF2 signaling pathways

Cited by 18 publications

References 46 publications

Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor

Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor

Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer

An Updated Review on Nelumbo Nucifera Gaertn: Chemical Composition, Nutritional Value and Pharmacological Activities

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