Nuchal-type fibroma

Michal, Michal; Fetsch, John F.; Hes, Ondřej; Miettinen, Markku

doi:10.1002/(sici)1097-0142(19990101)85:1<156::aid-cncr22>3.0.co;2-o

Cited by 105 publications

(23 citation statements)

References 34 publications

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“…While Gardner fibroma and nuchal fibroma share poor circumscription, hypocellularity, and sparse bland nuclei without atypicality or mitosis, they differ in consistency (rubbery vs. hard), and collagen pattern (formless, pattern‐less sheets vs. lobulated thick collagen bundles with criss‐crossing pattern) 16 . In addition, unlike Gardner fibroma, which rarely shows entrapped nerves, but much like nuchal‐type fibroma, 50–89% of extra nuchal‐type fibromas exhibit traumatic neuroma‐like areas and less commonly Morton's neuroma‐like areas 2,5,10 . Whether these neural changes occur in reaction to tumor entrapment, injury from contusion or minor repetitive trauma is unknown 5,10,15 .…”

Section: Discussionmentioning

confidence: 99%

“… Trauma, minor repetitive, is one suspected etiology of nuchal‐type fibromas 2 . At the dermal‐subcutaneous junction near the border of the nuchal‐type fibroma was a large nerve fascicle associated with mild fibrosis and smaller, ramifying nerve twigs implicating the co‐existence of traumatic neuroma.…”

Section: Case Reportmentioning

confidence: 99%

“…Nuchal‐type fibroma or collagenosis nuchae represents a rare fibrous tumor‐like proliferation that occurs mainly on the back of the neck of adult males 1,2 . Occasionally, nuchal‐type fibroma affects non‐nuchal sites and can be associated with diabetes mellitus (DM), scleredema or Gardner's syndrome 3–12 .…”

Section: Introductionmentioning

confidence: 99%

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Extra nuchal-type fibroma associated with elastosis, traumatic neuroma, a rare APC gene missense mutation, and a very rare MUTYH gene polymorphism: a case report and review of the literature*

Linos

Sedivcova

Černá

et al. 2011

Journal of Cutaneous Pathology

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We report a case of an extra nuchal-type fibroma in a 51-year-old male suspected to have attenuated familial adenomatous polyposis (Gardner's syndrome), who presented with a longstanding buttock mass excised due to enlargement and pain. Histopathologically, lobules of haphazard, hypocellular, hyalinized collagen bundles replaced the dermis and subcutis and entrapped nerve bundles, mimicking Morton neuroma. Ramifying nerve twigs found around larger nerve fascicles showed the co-existence of traumatic neuroma. Elastic tissue stain revealed elastosis characterized by large, arborizing fibers lying between and within the hyalinized collagen bundles. Modified Masson's trichrome stain showed light blue staining of collagen bundles producing the hyalinized nodules with irregular, light red staining of collagen bundles at their periphery and within tumor collagen. Compression and/or degeneration of collagen and secondary elastosis with later entrapment by tumor collagen could explain this microscopic phenotype. By immunohistochemistry, tumor spindle cells expressed nuclear β-catenin and cyclin D1, mostly within regions of fibrosis implicating activation of the adenomatous polyposis coli (APC)-Wnt pathway. Genetic analysis showed a missense mutation in APC gene (c.7504G>A, p.G2502S in exon 15) and a functional homozygous polymorphism in the MUTYH gene (c.36+325G>C, (IVS1+5G/C)). Nuchal-type fibroma has been associated with Gardner's syndrome and trauma. In this patient, genetic predisposition coupled with repetitive, localized trauma and collagen degeneration may have provided the stimulus for the development of extra nuchal-type fibroma.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Extra nuchal-type fibroma associated with elastosis, traumatic neuroma, a rare APC gene missense mutation, and a very rare MUTYH gene polymorphism: a case report and review of the literature*

Linos

Sedivcova

Černá

et al. 2011

Journal of Cutaneous Pathology

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“…Nuchal fibroma is predominantly subcutaneous but may extend to the dermis. 1 Conversely, scleredema is largely dermal but may involve the subcutis. 5 Whether nuchal fibroma and scleredema are part of the same spectrum of disease remains to be confirmed.…”

Section: Discussionmentioning

confidence: 99%

“…One large and two small series have been reported, as well as solitary case reports. 1–6 Nuchal fibroma does not tend to recur after excision and has not been reported to undergo malignant change. It has been associated recently with diabetes mellitus and Gardner’s syndrome.…”

Section: Introductionmentioning

confidence: 99%

Nuchal fibroma associated with scleredema, diabetes mellitus and organic solvent exposure

2000

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A case of scleredema diabeticorum of Buschke associated with nuchal fibroma and organic solvent exposure is reported. The patient presented with a neck mass causing discomfort and restriction of movement. Histological examination showed this to be a nuchal fibroma. Additionally, there was widespread induration of the skin of his trunk which was asymptomatic. A biopsy showed features of scleredema. This is the first reported association of these two conditions, both of which show increased and thickened collagen bundles without significant fibroblast proliferation. They differ by the occurrence of mucin in scleredema, although this is not always demonstrable, particularly in late lesions. The possibility that nuchal fibroma is an end stage, localized form of scleredema is canvassed. The patient's medical history included insulin-dependent diabetes mellitus with complications of retinal vessel thrombosis and peripheral neuropathy. The patient also had significant past exposure to a wide variety of chemicals, including organic solvents.

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Soft‐Tissue Tumours and Tumour‐Like Conditions

Calonje

2004

Rook's Textbook of Dermatology

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Nuchal-type fibroma

Cited by 105 publications

References 34 publications

Extra nuchal-type fibroma associated with elastosis, traumatic neuroma, a rare APC gene missense mutation, and a very rare MUTYH gene polymorphism: a case report and review of the literature*

Extra nuchal-type fibroma associated with elastosis, traumatic neuroma, a rare APC gene missense mutation, and a very rare MUTYH gene polymorphism: a case report and review of the literature*

Nuchal fibroma associated with scleredema, diabetes mellitus and organic solvent exposure

Soft‐Tissue Tumours and Tumour‐Like Conditions

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