NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives

Pelch, Katherine E.; Wignall, Jessica A.; Goldstone, Alexandra E.; Ross, Pam; Blain, Robyn; Shapiro, Andrew James; Holmgren, Stephanie; Hsieh, Jui-Hua; Svoboda, Daniel; Auerbach, Scott S.; Parham, Frederick; Masten, Scott A.; Thayer, Kristina A.

doi:10.22427/ntp-rr-4

Cited by 14 publications

(16 citation statements)

References 402 publications

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“…Because BPA, BPAF, and BPS are all considered to act as endocrine disruptors ( Pelch et al. 2017 ), and specifically act on estrogen receptors, we wanted to test whether an early-life exposure could alter global nuclear receptor expression in the mammary gland and potentially pose as a mechanistic underpinning for phenotypic effects seen later in life.…”

Section: Resultsmentioning

confidence: 99%

“…BPA is considered an estrogenic compound, and therefore we were interested in determining if there would be changes in serum hormone concentrations well after prenatal exposure to BPA, BPAF, or BPS. Both BPAF and BPS have been shown to be agonists for

, ( Pelch et al. 2017 ) and produce proliferative effects in MCF-7 cells ( Hashimoto et al.…”

Section: Discussionmentioning

confidence: 99%

“…2014 ). The combination of FDA’s BPA use restrictions and voluntary recalls by some manufacturers have led to the integration of other bisphenol analogues that demonstrate similarity in structure and activity to BPA ( Pelch et al. 2017 ) into paper- and food-containing products, dental sealants, or food-processing equipment.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice

Tucker

Bouknight

Brar

et al. 2018

Environ Health Perspect

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Background:Continued efforts to phase out bisphenol A (BPA) from consumer products have been met with the challenges of finding safer alternatives.Objectives:This study aimed to determine whether early-life exposure to BPA and its related analogues, bisphenol AF (BPAF) and bisphenol S (BPS), could affect female pubertal mammary gland development and long-term mammary health in mice.Methods:Timed pregnant CD-1 mice were exposed to vehicle, BPA (0.5, 5, 50mg/kg), BPAF (0.05, 0.5, 5mg/kg), or BPS (0.05, 0.5, 5mg/kg) via oral gavage between gestation days 10–17. Mammary glands were collected from resulting female offspring at postnatal day (PND) 20, 28, 35, and 56, and at 3, 8, and 14 months for whole mount, histopathological evaluation, and quantitative real-time polymerase chain reaction (qPCR); serum steroid concentrations were also measured at these time points.Results:In the bisphenol-exposed mice, accelerated mammary gland development was evident during early puberty and persisted into adulthood. By late adulthood, mammary glands from bisphenol-exposed female offspring exhibited adverse morphology in comparison with controls; most prominent were undifferentiated duct ends, significantly more lobuloalveolar hyperplasia and perivascular inflammation, and various tumors, including adenocarcinomas. Effects were especially prominent in the BPAF 5mg/kg and BPS 0.5mg/kg groups. Serum steroid concentrations and mammary mRNA levels of Esr1, Pgr, Ar, and Gper1 were similar to controls.Conclusions:These data demonstrate that prenatal exposure of mice to BPAF or BPS induced precocious development of the mammary gland, and that siblings were significantly more susceptible to spontaneous preneoplastic epithelial lesions and inflammation, with an incidence greater than that observed in vehicle- and BPA-exposed animals. https://doi.org/10.1289/EHP3189

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Section: Resultsmentioning

confidence: 99%

, ( Pelch et al. 2017 ) and produce proliferative effects in MCF-7 cells ( Hashimoto et al.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice

Tucker

Bouknight

Brar

et al. 2018

Environ Health Perspect

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“…Mass quantities of BPAF are now being produced in the United States annually, and recently, BPAF was detected in food, dust, sediment, and municipal sewage sludge (Chen D et al. 2016; Pelch et al. 2017).…”

Section: Introductionmentioning

confidence: 99%

Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure

Jones

Lang

Kendziorski

et al. 2018

Environ Health Perspect

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Background: Endometriosis is a gynecological disease affecting 1 in 10 women of reproductive age. Endometriosis incidence has risen; however, whether this rise is due to disease awareness or environmental contamination is not known. Objective: The objective of this study was to determine if bisphenol A (BPA) or bisphenol AF (BPAF) potentiate the development of endometriosis and if hormonal status alters how toxicant exposure affects disease. Methods: A mouse model of endometriosis, where minced uterine tissue is injected into the peritoneal cavity of a host mouse, was used to examine the effects of BPA and BPAF on endometriosis lesion development in ovariectomized and hormonally intact mice. BPA and BPAF were delivered through diet to include no-observed-adverse-effect-level (NOAEL) and the low-observed-adverse-effect-level (LOAEL) exposure levels. After six weeks (at necropsy), lesions, ovaries, and blood were collected to examine characteristics, gene expression, and hormonal regulation. Results: BPA and BPAF treatments affected endometriosis in a manner specific to dose and hormonal status of the host mouse. Estrogen and endometriosis-mediated differences in lesion target gene expression also depended on hormonal status. In intact mice, ovarian steroidogenic pathways were disrupted, progesterone levels were lowered, and atretic oocyte numbers were higher with toxicant exposure. BPAF, more so than BPA, resulted in more endometriosis lesion growth, but both toxicants disrupted normal ovarian signaling. Conclusion: These findings further our understanding of the effects and hormonal impacts of BPA and BPAF on endometriosis perturbation in ovariectomized and hormonally intact mice. BPAF appeared to be similar if not more estrogenic than BPA and may be affecting an environmental contribution of the increased incidence of endometriosis. https://doi.org/10.1289/EHP3802

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“…As a result of these BPA limits, industrial establishments are progressively substituting BPA by means of other equivalent compounds (Pelch et al, 2017).…”

Section: Trace Analysis Of Environmental Endocrine Disrupting Contamimentioning

confidence: 99%

Trace analysis of environmental endocrine disrupting contaminant bisphenol A in canned, glass and polyethylene terephthalate plastic carbonated beverages of diverse flavors and origin

et al. 2021

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Bisphenol A (BPA) is a hazardous contaminant demonstrating endocrine disrupting properties, and assumed to be involved in the pathogenesis of various cancer diseases for instance prostate, lung and breast cancer. The objective of the present study was to estimate the BPA amounts in carbonated beverages from the Saudi Arabian market for the first time using an authenticated technique based on solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. A total of thirty-four carbonated beverages of different flavors, origin and packaging materials were studied. The beverage production periods were from February 2018 to July 2018 containing volume (250-1000 mL), packaging materials were of canned, glass and polyethylene terephthalate (PET) plastic. BPA amounts in canned (0.64-11.41 µg/L), glass bottled (1.92-29.56 µg/L) and PET plastic bottled (0.37-21.83 µg/L) were obtained with recovery (97.64-99.96%). Relatively, glass bottled has offered higher amounts of BPA compared to PET plastic bottled and canned samples. The unforeseen presence of BPA especially in glass bottled emphasizes the ubiquity of such compound beside the food fabrication chain, far off to the food packaging materials. Thus, a further knowledge on BPA amounts in glass bottled samples, in addition to threat assessment studies, is essential to defend human health.

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NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives

Cited by 14 publications

References 402 publications

Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice

Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice

Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure

Trace analysis of environmental endocrine disrupting contaminant bisphenol A in canned, glass and polyethylene terephthalate plastic carbonated beverages of diverse flavors and origin

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