2024
DOI: 10.1002/mc.23688
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NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple‐negative breast cancer by blocking the EGFR pathway

Rui Sang,
Xiaoping Yu,
Han Xia
et al.

Abstract: Triple‐negative breast cancer (TNBC) is an exceptionally aggressive breast cancer subtype associated with neuropathic pain. This study explores the effects of 5′‐nucleotidase domain‐containing protein 2 (NT5DC2) on the progression of TNBC and neuropathic pain. Microarray analysis was conducted to identify differentially expressed genes in TNBC and the pathways involved. Gain‐ and loss‐of‐function assays of NT5DC2 were performed in TNBC cells, followed by detection of the extracellular acidification rate, adeno… Show more

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