NT-proBNP is not elevated in patients with obstructive sleep apnoea

Abstract

Our results show by a robust multiple regression analysis, that NT-pro BNP is not associated with OSAS and NT-pro BNP cannot be used as a sensitive marker for underlying cardiovascular abnormalities in patients with OSAS.

Sleep Apnea in Total Joint Arthroplasty Patients and the Role for Cardiac Biomarkers for Risk Stratification: an Exploration of Feasibility

“…This phenomena was also observed by Hubner and colleagues, who did not find any association between NTproBNP levels and OSA severity either before or after nasal or bi-level CPAP; however, NT-proBNP levels were associated with impaired left ventricular ejection fraction and systemic arterial hypertension [149]. NTproBNP levels were reduced following nasal CPAP in a handful of patients but this finding was not significant quite possibly due to the small number of patients in this subgroup [149].…”

“…Following 1 and 3 months of nCPAP, Tei index decreased in OSA group; and prevalence of GLVD decreased from 19 to 4% [62] Usui et al Hubner et al echocardiography; 28 out of 60 patients were re-evaluated 3 months following PAP treatment NT-proBNP levels were not associated with AHI. Increased NT-proBNP levels correlated with left ventricular ejection fraction, creatinine clearance and arterial hypertension [149] Tasci et al cohort [47], and a 3.5-fold odds of death [24], 6.9-fold odds of cardiovascular related mortality following vascular surgery [24].…”

“…Brain natriuretic peptides as a marker of cardiovascular risk in OSA The majority of studies evaluating BNPs in patients with OSA found no association between levels of BNP and OSA severity [62,64,66,[69][70][71]73,133,134,149,150], although some studies have found an association [63] (see Table 6). Association between BNP levels and OSA severity appears most useful in select sub-groups including a cohort of only women, or in patients with varying severity of coronary artery disease (CAD).…”

“…The effects of PAP therapy on BNP levels have been mixed, with a number of studies demonstrating PAP did not significantly alter levels of BNPs [64,73,133,134] versus other studies observing PAP decreased levels of BNPs [62,69,135,149] (see Table 6). However, some evidence seems to suggest that significant changes in BNP levels with PAP therapy occurs, particularly in patients with OSA and known left ventricular dysfunction or who have pre-existing cardiovascular risk factors.…”

Markers of Myocardial Ischemia in Patients with Diabetes Mellitus and Severe Obstructive Sleep Apnea – Impact of Continuous Positive Airway Pressure Therapy

“…CPAP treatment had no effect on hs-cTnT and NT-proBNP levels in patients without heart failure in both groups despite significant reduction in AHI. In a study by Ljunggren a dose-response relationship between the severity of sleep apnea during the night and the levels of BNP in the morning was seen [27] while other studies found no correlation between OSA severity and NT-proBNP concentration [22,[28][29][30].…”