NT-proBNP in cardiac surgery: a new tool for the management of our patients?

Reyes, Guillermo; Forés, Gloria; Rodríguez-Abella, R. Hugo; Cuerpo, Gregorio; Vallejo, José Luis; Romero, Carlos; Pinto, Ángel González

doi:10.1510/icvts.2004.101576

Cited by 19 publications

(21 citation statements)

References 20 publications

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“…Here we found that there was no correlation between pre-operative or post-operative NT-proBNP and aortic cross-clamping time in CVR, which was similar to other results (15)(16)(17)(18), but it was different from the results of Berendes et al or Rafal et al (8,19). Their studies showed that BNP correlated with aortic cross-clamping time.…”

Section: Discussionsupporting

confidence: 78%

N-terminal pro-Brain natriuretic peptide as a useful biomarker for monitoring prognosis in patients with cardiac valve replacement

Cai

Wang

Liu

et al. 2011

J. Clin. Lab. Anal.

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Section: Discussionsupporting

confidence: 78%

N-terminal pro-Brain natriuretic peptide as a useful biomarker for monitoring prognosis in patients with cardiac valve replacement

Cai

Wang

Liu

et al. 2011

J. Clin. Lab. Anal.

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“…The levels of Nt-proBNP increased significantly compared to baseline levels from the first to the 4 th postoperative day with a peak at 2 nd day. Our results are consistent with those of Reyes et al [10] In this study, preoperative levels of Nt-proBNP (1371 ± 759.9 pg / ml with a median of 366 pg/ml) increased significantly after CPB surgery from postoperative day 1 to the 4 th postoperative day. In their study including 83 patients, no difference in the type of surgery was reported.…”

Section: Discussionsupporting

confidence: 93%

“…In their study including 83 patients, no difference in the type of surgery was reported. [10] The study of Berendes et al [11] also showed a significant increase in BNP levels after cardiac surgery. However, in their study, including 60 CABG and 43 VR patients, BNP levels were significantly increased in VR patients as compared to CABG ones.…”

Section: Discussionmentioning

confidence: 94%

N-terminal pro-brain natriuretic peptide identifies patients at risk for occurence of postoperative atrial fibrillation in cardiac surgery with cardiopulmonary bypass

et al. 2012

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Atrial fibrillation (AF) is the most common arrhythmia after cardiac surgery with cardiopulmonary bypass (CPB).The value of N-terminal (Nt)-pro brain natriuretic peptide (BNP) in predicting AF complicating cardiac surgery is not well studied. Our objective is to determine its predictive value in the occurrence of AF after cardiac surgery with CPB. In a prospective observational study, including patients scheduled for cardiac surgery with CPB, we collected blood samples for each patient: the first one immediately after the induction of anesthesia and before CPB. The subsequent samples were taken at the end of the CBP (H0), 4 hours later (H4), and every day during the first four days (H24, H48, H72 and H96). Nt-proBNP and cardiac troponin (cTnI) were measured in each sample. The levels of Nt-proBNP were significantly increased in patients who developed AF. The receiver operating characteristic curve (ROC) analysis of Nt-proBNP studied at different times showed that assays at the end of the CPB and at H4 had the maximum area under the curve (AUC). A threshold value of 353.5 pg/mL of Nt-proBNP at the end of the CPB showed a sensitivity of 71% and a specificity of 84% for the prediction of AF and an AUC of 0.711. The threshold value (307.5 pg/mL) of Nt- proBNP measured at H4 had the same sensitivity but a lower specificity (74%) and AUC = 0.709. We conclude that Nt-proBNP values of 353 and 307 pg/mL at 0 and 4 hour after CPB could predict occurrence of AF.

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“…The perioperative release pattern of copeptin in our study differs to natriuretic peptides. In uncomplicated cardiac surgery patients NT-proBNP raise until day 3-4 postoperatively and thereafter start to decline 25 . This difference in temporal release curves may illustrate the fact that NT-proBNP and copeptin are secreted as respons to different aspects of stress during heart surgery.…”

Section: Discussionmentioning

confidence: 99%