NT-PROBNP: A Biochemical Marker of Maternal Complications in Pre-eclampsia

Kumari, Supriya; Gupta, Meenu; Vardhan, Harsh; Saini, Vandana; Gupta, SK

doi:10.7860/jcdr/2017/28713.10855

Cited by 5 publications

(19 citation statements)

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“…This observation was similar to Murat Bakacak et al, Kumari S et al who also found NT-pro-BNP levels significantly higher in severe preeclampsia group compared with mild preeclampsia group (p < 0.001). 24,25 At 3 months postpartum resolution of NT-pro-BNP in both the groups was found to be complete. Persistent serum NT-pro-BNP was observed in eight women at the end of 6 weeks in group B.…”

Section: Discussionmentioning

confidence: 92%

Preeclampsia: Postpartum Resolution of Hypertension, Proteinuria and Serum N-terminal B-type Natriuretic Peptide

Gupta¹,

Gupta²,

Saini³

et al. 2019

Indian Journal of Medical Biochemistry

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Background: Postpartum persistent proteinuria and hypertension (HT) is associated with development of chronic kidney disease and cardiovascular disease in later life. AIMS & OBJECTIVES: To evaluate blood pressure, proteinuria and serum NT-pro-BNP in proteinuric preeclamptic (PE) women and study their postpartum resolution till 3 months and determine the associated risk factors. Material and methods: 100 PE women enrolled included 66 women with mild (group A) and 34 with severe PE (group B). BP, urinary protein:creatinine(P/C) ratio, S.NT-pro-BNP were evaluated at labor room admission, postpartum day 1, 6 weeks and 3 months. Results: Group B women had significant higher baseline BP, urine P/C ratio and S. NT-pro-BNP compared to group A. Resolution of BP, proteinuria and S. NT-pro-BNP was complete in group A women at 6 weeks postpartum. Persistent hypertension was observed in 25 and 4 women at postpartum 6 weeks and 3 months respectively. Proteinuria persisted in 25 and 10 women at postpartum 6 weeks and 3 months respectively. Resolution of NT-pro-BNP was complete at 3 months. In logistic regression model persisting hypertension and proteinuria at 3 months was correlated with increasing age, higher BMI and lower gestational age at delivery. Negative predictive value of 100% was observed with baseline P/C ratio <5, BP <120 mm Hg diastolic and S.NT-pro-BNP <1000 pg/mL for development of persistent proteinuria and hypertension. Conclusion: Women with severe PE should be followed up for persistent proteinuria and hypertension. These women require evaluation for chronic kidney disease and preventive strategies for cardiovascular disease.

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Section: Discussionmentioning

confidence: 92%

Preeclampsia: Postpartum Resolution of Hypertension, Proteinuria and Serum N-terminal B-type Natriuretic Peptide

Gupta¹,

Gupta²,

Saini³

et al. 2019

Indian Journal of Medical Biochemistry

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“…The index tests are plasma NT-proBNP assays using any method. NT-proBNP is an index widely used to evaluate cardiac function (11). Elevated NT-proBNP plasma levels are associated with preeclampsia and its complication (11).…”

Section: Index Testmentioning

confidence: 99%

“…The NT-proBNP level is signi cantly increased in preeclampsia women compared to patients with normal pregnancy (10). The NT-proBNP level also continues to increase during the 3 to 6 months postpartum (11). This makes NT-proBNP can be used as a biomarker to screen for preeclampsia cardiovascular complication before and after labor.…”

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confidence: 98%

The Role of NT-proBNP as Prognostic Biomarker for Preeclampsia Complications: A Systematic Review Protocol

Asaduddin

Anshari

Ali

et al. 2021

Preprint

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Background There are two central dogmas between the pathophysiology of preeclampsia, the placental origin and the extra-placental origin. Recent findings found that women with a history of preeclampsia are at higher risk of cardiovascular disease and death because of cardiovascular disease. This finding leads to the extra-placental origin. During normal pregnancy, the maternal cardiovascular system undergoes modification. However, hemodynamic and vascular modification are disrupted in women who develop preeclampsia. NT-proBNP is a biomarker that indicates the disruption of the cardiovascular system and can predict the complication of preeclampsia. Based on that information, we would like to investigate the roles of NT-proBNP plasma levels in predicting maternal and fetal complications of preeclampsia women. Besides, we also investigate the roles of NT-proBNP plasma levels in predicting the severity and onset of preeclampsia women and the sensitivity and specificity of NT-proBNP plasma levels in preeclamptic women.MethodsWe designed and registered a study protocol for a systematic review. This study aims to investigate the roles of NT-proBNP plasma levels in predicting maternal and fetal complications of preeclampsia women. The Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy was used to structure our methodological approach and the Preferred Reporting Items for a Systematic Review and Meta-Analysis Protocols guidelines in reporting the findings of this review. We will search literature in Hinari, Cochrane Library, ScienceDirect, and Scopus database. Then, we will search the grey literature in OCLC’s OAISTER. Randomized controlled trials and observational studies will be included in the analysis. Three reviewers will independently screen articles, extract data, and evaluate for quality and bias using Newcastle-Ottawa Scale. Studies were included according to the following procedures: (1) Identification, Duplication of articles and non-original research articles will be excluded; (2) Title and Abstract Screening, RCT and observational studies and focused on NT-proBNP levels in preeclampsia; (3) Full-text availability; and (4) Full-text screening based on PICO criteria. Each outcome is synthesized by a qualitative or narrative approach. The results will be divided into certain points, namely (a) Selection of the studies, (b) Characteristics of the Eligible Studies, (c) Data Extraction of the Eligible Studies, and (d) Risk of Bias Analysis Results.Discussion A systematic review of the role of NT-proBNP as predicting biomarkers for preeclampsia complications will be conducted. This study can help predict the severity, onset, and complication of a pregnant woman with preeclampsia.

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“…NT-proBNP levels in women with preeclampsia, eclampsia, and hemolysis, elevated liverenzymes and Low Platelets (HELLP) syndrome are elevated, reflecting increased left ventricular filling pressure and left ventricular diastolic and/or subclinical cardiac dysfunction. 3 , 4 NT-proBNP is also increased in participants with preterm preeclampsia and multiplies many times their risk of cardiovascular complications, but the mechanism remains unclear. The changes in the vascular system in preeclampsia are not similar to normal pregnancy, but rather an increase in vasoconstriction, thereby increasing the burden on the heart and altering the function and structure of the left ventricle.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have indicated that preeclampsia patients with severe signs have an increased risk of future cardiovascular disease than healthy women. 3 Therefore, we carried out this study to evaluate cardiac function using transthoracic echocardiography and serum NT-proBNP level in a cohort of women with PE.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of NT-Pro BNP in Patients with Preeclampsia

Nguyen¹,

Nguyen²,

Nguyen-Phan³

et al. 2022

IBPC

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Objective This study aims to determine the serum levels of NT-proBNP in women with preeclampsia with and without severe signs and to evaluate the cardiovascular risks in these two groups of participants. Methods A descriptive cross-sectional study was conducted on 52 women with preeclampsia in the Department of Gynecology and Obstetrics – Hue Central Hospital, from August 2019 to September 2020. Results In preeclampsia women, the rate of hypertension in stage 3, stage 2, and stage 1 were 46.1%, 32.7%, and 21.2%, respectively. The average Sokolow-Lyon index in the preeclampsia group with and without severe signs was 22.25 ± 7.38mm, 20.16 ± 5.54mm, respectively. The average left ventricular mass index in the group of preeclampsia patients without and with severe signs was 92.27 ± 14.56g/m 2 and 120.68 ± 16.47g/m 2 , respectively. The average ejection fraction in the group of preeclampsia patients without severe signs and with severe signs was 65.11 ± 3.45%, 56.21 ± 7.12%, correspondingly. In contrast, the difference between the two groups was statistically significant with p < 0.05. The plasma NT-proBNP level in the preeclampsia group without severe signs was 349.12 ± 93.51pg/mL, whereas the concentration in the preeclampsia group with severe signs was 725.32 ± 290.46pg/mL (p < 0.05). Conclusion The NT-proBNP level was statistically significantly increased in the patients with preeclampsia. Analyzing and comparing the figures and changes found in two groups of PE patients, with and without severe signs, we suggest that women diagnosed with PE with severe signs have a higher risk of developing cardiovascular problems forthwith and henceforth.

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NT-PROBNP: A Biochemical Marker of Maternal Complications in Pre-eclampsia

Cited by 5 publications

References 0 publications

Preeclampsia: Postpartum Resolution of Hypertension, Proteinuria and Serum N-terminal B-type Natriuretic Peptide

Preeclampsia: Postpartum Resolution of Hypertension, Proteinuria and Serum N-terminal B-type Natriuretic Peptide

The Role of NT-proBNP as Prognostic Biomarker for Preeclampsia Complications: A Systematic Review Protocol

Serum Levels of NT-Pro BNP in Patients with Preeclampsia

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