NSFC spurs significant basic research progress of respiratory medicine in <scp>C</scp>hina

Sun, Rui-Juan; Xu, Feng; Wang, Chen; Dong, Erbao

doi:10.1111/crj.12351

Cited by 2 publications

(1 citation statement)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of asthma remains high worldwide. As a chronic airway inflammatory disease, asthma not only harms patient's physical and mental health, but is also considered a burden to society (1,2). There are several clinical interventions used to treat asthma, including traditional treatment with glucocorticoids; however, the effects of treatment are not always satisfactory.…”

Section: Introductionmentioning

confidence: 99%

CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation

Wang

Zhu

Chen

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

Predominant T helper (Th)2 and impaired Th1 cell polarization has a crucial role in the development of asthma. Cluster of differentiation (CD)38 is associated with the increased release of interleukin (IL)‑12 from dendritic cells (DCs) and DC‑induced Th1 cell polarization. However, whether CD38 expression affects DC function in asthma development remains unknown. In the current study, adenoviruses were constructed containing the murine CD38 gene. Overexpression of CD38 protein level in DCs induced from bone‑marrow derived DCs (BMDCs) by recombinant mouse granulocyte macrophage colony‑stimulating factor and IL‑4 was achieved through 24 h adenovirus infection. The results demonstrated that BMDCs with CD38 overexpression exhibited no phenotypic change; however, following stimulation with lipopolysaccharide (LPS), maturation and IL‑12 secretion were increased. In addition, CD38‑overexpressing BMDCs stimulated with LPS exhibited more effective Th1 cell differentiation. Mice that were administered CD38‑overexpressing BMDCs exhibited milder symptoms of asthma. Furthermore, decreased IL‑4, IL‑5 and IL‑13 levels were detected in bronchoalveolar lavage fluid (BALF), reduced immunoglobulin E levels were measured in the sera, and increased interferon‑γ was detected in BALF from the recipients of CD38‑overexpressing BMDCs. Increased phosphorylated‑p38 expression was also detected in LPS-stimulated CD38-overexpressing BMDCs, whereas pretreatment with a p38‑specific inhibitor was able to abolish the effects of LPS stimulation and CD38 overexpression on IL‑12 release and Th1 cell differentiation in BMDCs. These results suggested that CD38 may be involved in the DC function of alleviating asthma via restoration of the Th1/Th2 balance, thus providing a novel strategy for asthma therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation

Wang

Zhu

Chen

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

Artificial selection versus natural selection: Which causes the Matthew effect of science funding allocation in China?

Zhang

Xiong

Wang

et al. 2020

Science and Public Policy

View full text Add to dashboard Cite

To investigate either artificial or natural selection leads to the Matthew effect in the science funding allocation and its consequences, this study retrieves 274,732 publications by Chinese scientists from the Web of Science and examines how the disparity of science funding determines scientists’ research performance. We employ the Negative Binomial Model and other models to regress the publication’s citation times, which measures the research performance, on the number of funding grants and their amounts of currency that the publication receives, which measures the disparity of science funding. The empirical results suggest an inverted U-shaped relationship. However, the optimum number of funding grants far exceeds the actual number that most publications receive, implying that increasing the funding for academic research positively impacts scientists’ research performance. The natural disparity thus plays a major role in distributing the science funding. Additionally, China’s publication-based academic assessment system may be another main cause.

show abstract

NSFC spurs significant basic research progress of respiratory medicine in China

Cited by 2 publications

References 123 publications

CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation

CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation

Artificial selection versus natural selection: Which causes the Matthew effect of science funding allocation in China?

Contact Info

Product

Resources

About