“…Several randomized trials have been carried out to answer the question whether nonplatinum combination regimens were as effective or even more active than platinum-based ones. In general, no single study was successful in demonstrating a survival advantage in favour of platinum-based regimens [21][22][23]. However, in some studies, a trend towards a higher ORR, or PFS or OS was observed in patients treated with platinum-based combinations compared with those treated with cisplatinum-devoid regimens [24][25][26][27].…”