NSAIDs Are Associated with Lower Depression Scores in Patients with Osteoarthritis

The Promise and Limitations of Anti-Inflammatory Agents for the Treatment of Major Depressive Disorder

“…In the five included studies that compared ibuprofen, naproxen, celecoxib with placebo in patients with osteoarthritis improvement in OA symptoms was strongly associated with improvements in depressive symptoms. [35] A similar picture emerges from studies examining the impact of cytokine antagonists on depressive symptoms in patients with psoriasis. While a large study that compared the TNF antagonist etanercept with placebo found that improvements in depression did not correlate with improvements in psoriasis symptoms (although improvements in fatigue did correlate with improvements in psoriasis) [36], two subsequent studies found medium to large effect-size correlations between improvements in depression and psoriasis in response to treatment with the TNF antagonist adalimumab (r ¼ 0.50, p < 0.0001) and the IL-12/IL-23 antagonist ustekinumab (r ¼ 0.32, p < 0.0001) [37,38].…”

“…In the final cytokine antagonist study in psoriasis approximately 33% of participants qualified for having depression based on a Zung score !50 [37]. In the 5 trials comparing celecoxib, naproxen, ibuprofen, and placebo in patients with OA, baseline scores were even lower (average score of 3 on the 9-item Patient Health Questionnaire, with moderate depression starting at a score of 15) [35]. The same issue plagues the largest study of healthy individuals included in the Kohler et al meta-analysis (N ¼ 2233) [39].…”

Antidepressant-like effects of Dipyrone researched with forced swim test

“…Klinik ve deneysel çalışmalarda birçok analjezik ilacın antidepresif etkisi olduğu görülmüştür [22][23][24][25][26][27][28][29] . Selektif COX2 inhibitörü selekoksib verilmiş hastalarda yapılan çalışmada, 400 mg/gün uygulanan ilacın antidepresif benzeri etkisi ortaya konmuştur 24 .…”

“…Farklı bir çalışmada ise selekoksibin daha düşük konsantarasyonda (200 mg/gün) uygulanmasıyla antidepresif etkinin ortaya çıktığı belirlenmiş, böylece yüksek konsantrasyonda kullanılan ilacın olası yan etkilerinden hastanın korunabileceği bildirilmiştir 25 . Yapılan farklı bir çalışmada ise, naproksen ve ibuprofen kullanan hastalarda antidepresif-benzeri etkinin oluştuğu ortaya konmuştur 26,27 . Antidepresanlarla tedavi görüp ilaç tedavisinden yeterince yararlanamayan hastaların tedavisine nonsteroid antiinflamatuvarların eklenmesi sonucu hastanın depresif bulgularının dü-zeldiği görülmüştür.…”

Osteoarthritis and Depression

“…На основании обобщенных данных пяти 6-недель-ных многоцентровых рандомизированных двойных сле-пых плацебоконтролируемых пострегистрационных иссле-дований показано [57], что терапия нестероидными проти-вовоспалительными препаратами (НПВП) -ибупрофе-ном, напроксеном, целебрексом -обеспечивает тенден-цию к уменьшению симптомов депрессии. По-видимому, это опосредованный противоболевой и противовоспали-тельный эффект.…”