NSAIDs and Cardiovascular Toxicity

Baker, William L.

doi:10.1016/b978-0-12-801238-3.95640-x

Cited by 2 publications

(2 citation statements)

References 104 publications

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“…It has been reported that NSAIDs inhibit the activity of cyclooxygenase-1 and cyclooxygenase-2 enzymes and thereby suppress the formation of thromboxane and prostaglandin (Bernardi et al, 2009;Bevaart et al, 2010). Chronic intake of NSAIDs leads to undesirable side effects such as gastrointestinal injury, renal and cardiovascular damages (Bjarnason et al, 2017;El-Yazbi et al, 2018;Baker, 2018).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats

Mostafa

El-Marasy

Jaleel

et al. 2020

Heliyon

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Evaluation of traditionally used royal jelly (RJ) for the management of hepato-renal damage and gastrointestinal ulcerations caused by diclofenac. Methods: Forty adult male Wistar rats were allocated into four groups. Rats of the 1 st group received only saline and served as normal group. The remaining 3 groups received diclofenac (50 mg/kg/day, I.P.) for 7 days. Group 2 served as diclofenac-control group. Groups 3 and 4 received RJ (150 and 300 mg/kg/day, P.O.) respectively for 30 days. Twenty-four hours after the last treatment, blood samples were collected, rats were sacrificed, and livers, kidneys, stomachs & intestines were harvested. Stomachs and intestines were tested for ulcer counts. Serum levels of AST, ALT, creatinine and urea were investigated. Hepatic, renal, gastric and intestinal tissue contents of myeloperoxidase (MPO) and prostaglandin-E2 (PGE2) were measured. Histopathological examinations were also performed followed by immunohistochemical determination of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. Results: Diclofenac administration caused significant deterioration of all the above mentioned parameters. RJ improved hepatic and renal functions. Gastric and intestinal ulcer counts were significantly ameliorated. Hepatic, renal, gastric and intestinal tissue PGE-2 contents and COX-2 expression were significantly elevated. RJ also significantly reduced MPO content and iNOS expression as compared to diclofenac-control group. Improvements of the histopathological pictures of hepatic, renal, gastric and intestinal tissues were also apparent. Conclusion:The study demonstrates promising protective effects of RJ against diclofenac-induced hepato-renal damage and gastrointestinal ulceration in rats.

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Section: Introductionmentioning

confidence: 99%

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats

Mostafa

El-Marasy

Jaleel

et al. 2020

Heliyon

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“…Numerous investigations have demonstrated their toxicities in rats, which include immediate pulmonary toxicity, serious injuries in the liver and brain, gastric damage, hepato-renal failure, and gastrointestinal ulcers (Aljuhani et al, 2019;Mostafa et al, 2020). use of NSAIDs causes unwanted side effects, including kidney, heart, and gastrointestinal problems (Baker, 2018;Bjarnason et al, 2018;El-Yazbi et al, 2018) . A common non-steroidal anti-inflammatory drug (NSAID) recommended due to its analgesic, anti-inflammatory, and antipyretic extended properties is diclofenac (Gan, 2010).…”

Section: Introductionmentioning

confidence: 99%

Biochemical and histopathological evaluation of the potential ameliorating effects of Spirulina platensis against acute hepatorenal toxicity of diclofenac sodium in male rats

Faraag,

Abdelhamid,

Elsenosi

et al. 2024

Benha Veterinary Medical Journal

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Non-steroidal anti-inflammatory drugs (NSAIDs) like diclofenac sodium (DFS) are used to treat pain, inflammatory conditions, and dysmenorrhea; however, the primary concerns with this medication are liver and kidney issues. The purpose of this study is to demonstrate the potential hepatoprotective and nephroprotective benefits of Spirulina platensis (SP) in rats exposed to DFS. Four equal groups of forty male rats were randomly assigned (10 each). The control group: rats received normal saline; SP group: rats were given SP orally 200 mg/kg b.wt dissolved in distilled water for 7 days; the DFS group: rats were received DFS orally 5 mg/kg b.wt dissolved in distilled water for 7 days; the DFS + SP group rats were received 5 mg /kg b.wt DFS with 200 mg/kg SP for 7 days. After the experiment was completed, serum samples were taken for evaluation of liver and kidney functions, and liver and kidney tissues were collected for histopathological examination. The results revealed that DFS administration for one week was followed by a significant increase in ALT and AST enzyme activities, a significant decrease in albumin concentration, and a significant increase in the levels of creatinine, urea, and uric acid when compared to the control group. However, concurrent oral administration of SP with DFS exhibited a moderate ameliorating effect against DFS hepatotoxicity and a powerful nephroprotective effect, as shown in the biochemical evaluations and confirmed with the histopathological examination. Therefore, it was concluded that Spirulina platensis had hepatonephroprotective effects against NSAID as diclofenac sodium used in the current study.

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NSAIDs and Cardiovascular Toxicity

Cited by 2 publications

References 104 publications

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats

Biochemical and histopathological evaluation of the potential ameliorating effects of Spirulina platensis against acute hepatorenal toxicity of diclofenac sodium in male rats

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