NS1: a promising novel target antigen with strong immunogenicity and protective efficacy for avian flavivirus vaccine development

Huang, Juan; Wang, Wanfa; Yu, Tingting; Wang, Mingshu; Liu, Mafeng; Zhu, Dekang; Chen, Shun; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Ou, Xumin; Mao, Sai; Tian, Bin; Sun, Di; He, Yu; Wu, Zhen; Jia, Renyong; Cheng, Anchun

doi:10.1016/j.psj.2024.103469

Cited by 1 publication

(2 citation statements)

References 41 publications

(50 reference statements)

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“…NS1 is one of the few NS genes capable of conducting retrograde complementation in stable expression replicase complexes [59]. NS1 plays a pivotal role in viral RNA replication, antiviral immunity, and host recognition of virus-associated molecular patterns [60,61].…”

Section: Non-structural Proteinsmentioning

confidence: 99%

“…Plasmid immunization platforms constructed based on TMUV NS1 can stimulate specific anti-NS1 IgG responses without inducing neutralizing antibodies against TMUV. NS1 demonstrates significant protective effects against TMUV attack without causing severe gross lesions [60]. Moreover, oral immunization of ducklings with Bacillus subtilis secreting DTMUV E protein effectively enhances resistance to DTMUV and significantly reduces virus titers (p < 0.01) while reducing pathological damage to the brain, heart, and spleen [49].…”

Section: Vaccinationmentioning

confidence: 99%

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Advancements in Research on Duck Tembusu Virus Infections

Cheng,

Wang,

et al. 2024

Viruses

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Duck Tembusu Virus (DTMUV) is a pathogen of the Flaviviridae family that causes infections in poultry, leading to significant economic losses in the duck farming industry in recent years. Ducks infected with this virus exhibit clinical symptoms such as decreased egg production and neurological disorders, along with serious consequences such as ovarian hemorrhage, organ enlargement, and necrosis. Variations in morbidity and mortality rates exist across different age groups of ducks. It is worth noting that DTMUV is not limited to ducks alone; it can also spread to other poultry such as chickens and geese, and antibodies related to DTMUV have even been found in duck farm workers, suggesting a potential risk of zoonotic transmission. This article provides a detailed overview of DTMUV research, delving into its genomic characteristics, vaccines, and the interplay with host immune responses. These in-depth research findings contribute to a more comprehensive understanding of the virus’s transmission mechanism and pathogenic process, offering crucial scientific support for epidemic prevention and control.

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Section: Non-structural Proteinsmentioning

confidence: 99%

Section: Vaccinationmentioning

confidence: 99%