NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy

Paganetti, Harald; Simone, Charles B.; Bosch, Walter R.; Haas-Kogan, Daphne; Kirsch, David G.; Li, Heng; Liang, Xiaoying; Liu, Wei; Mahajan, Anita; Story, Michael D.; Taylor, Paige A.; Willers, Henning; Xiao, Ying; Buchsbaum, Jeffrey C.

doi:10.1016/j.ijrobp.2024.07.2152

International Journal of Radiation Oncology*Biology*Physics

2024

DOI: 10.1016/j.ijrobp.2024.07.2152

|View full text |Cite

NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy

Harald Paganetti,

Charles B. Simone,

Walter R. Bosch

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 162 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Proton Therapy in Uveal Melanoma

Chan,

Lin,

Yacoub

et al. 2024

Cancers

View full text Add to dashboard Cite

Background/Objectives: Uveal melanoma is the most common primary intraocular malignancy in adults. Treatment options for localized, early-stage disease include enucleation, brachytherapy, and proton beam therapy. This review aims to evaluate the role of proton therapy in the definitive management of uveal melanoma, focusing on its physics, radiobiology, treatment techniques, and associated outcomes. Methods: This narrative review synthesizes current literature on proton therapy for uveal melanoma, emphasizing case selection, treatment efficacy, and side effects. Results: Proton therapy offers significant advantages for thicker uveal melanomas (over 8 mm) due to its unique physical properties, including a rapid dose fall-off that protects critical structures like the retina and optic nerve. Proton therapy may have benefits in tumor control for ocular melanomas given its increased relative biological effectiveness relative to photon therapy for these typically more radioresistant melanomas. Proton therapy may also hold special value for uveal melanomas in close proximity to the optic nerve, as patients are at high risk of visual toxicities with brachytherapy. The review discusses the efficacy of proton therapy across small, medium, and large tumors, along with strategies for improving patient survival through combined systemic therapy. Additionally, the potential of ocular reirradiation with proton therapy is addressed. Conclusions: Proton therapy is an effective treatment for uveal melanoma. It offers advantages over brachytherapy for large tumors, tumors that are close to the optic nerve or insertion of extra-ocular muscles.

show abstract

Proton Therapy in Uveal Melanoma

Chan,

Lin,

Yacoub

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy

Cited by 1 publication

References 162 publications

Proton Therapy in Uveal Melanoma

Proton Therapy in Uveal Melanoma

Contact Info

Product

Resources

About