Abstract:Background
Drug resistance is a particular problem in patients with temporal lobe epilepsy, where seizures originate mainly from the hippocampus. Many of these epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure and are characterized by pathophysiological mechanisms that synergistically mediate the secondary brain damage, prominently including massive oxidative stress that evolves over time, contributing to the development of epilepsy. The transcription factor nucle… Show more
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