Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice
Hao Yu,
Yanxia Peng,
Wenjuan Dong
et al.
Abstract:Objectives Methamphetamine (MA) abuse is a serious social problem worldwide. Cardiovascular complications were the second leading cause of death among MA abusers. We aimed to clarify the effects of MA on myocardial injury, oxidative stress, and apoptosis in myocardial cells and to explore the potential mechanism of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) in MA-induced oxidative stress and apoptosis. Methods An acute cardiac toxicity model of MA was established by intraperitoneal injection of … Show more
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