NrF2/ARE and NF-κB Pathway Regulation May be the Mechanism for Lutein Inhibition of Human Breast Cancer Cell

Chang, Jingzhi; Zhang, Yuxia; Li, Yichuan; Lu, Kun Ping; Shen, Yongjie; Guo, Yu; Qi, Qingfeng; Wang, Mingchen; Zhang, Shanfeng

doi:10.2217/fon-2017-0584

Cited by 48 publications

(39 citation statements)

References 29 publications

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“…Numerous studies have shown that NF‐κB is an important inflammatory transcriptional regulator that can be activated by oxidative stress . Under normal circumstances, NF‐κB is composed of multiple subunits in the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…However, some reseachers have found that the activated Nrf2 pathway may induce other relevant mechanisms to inhibit proliferation of tumor cells and promote apoptosis. One possible mechanism is to induce the expression of Nrf2 and its nuclear import, and thus promote the expression of antioxidant enzymes to reduce the production of ROS, thereby inhibiting tumor cell proliferation and promoting apoptosis …”

Section: Introductionmentioning

confidence: 99%

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Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

Zhang

Wang

et al. 2019

Annals of the New York Academy of Sciences

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Resveratrol (Res) is a polyphenolic compound that has a variety of biological functions and activities. This study aimed to explore the mechanisms of the antioxidant and proapoptotic effects of Res in H2O2‐treated rheumatoid arthritis fibroblast‐like synoviocytes (RA‐FLSs) by the Nrf2–Keap1 signaling pathway. We found that 5 µM H2O2 promoted cell proliferation and increased intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) content in RA‐FLSs. However, Res could reverse these effects in 5 µMH2O2‐treated RA‐FLSs by (1) promoting expression of nuclear factor erythroid 2–related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1), (2) reducing expression of Kelch‐like ECH–related protein 1 (Keap1), (3) inhibiting production of ROS and MDA, (4) blocking activation of nuclear factor‐κB (NF‐κB) p65, (5) inhibiting cell proliferation and migration, and (6) activating Bcl‐2/Bax to induce apoptosis. After lentiviral silencing of Nrf2 (siNrf2) mRNA expression in RA‐FLSs, Res addition did not increase the expression of Nrf2 or HO‐1 to reduce the production of mitochondrial ROS caused by 5 µM H2O2. Res reduced the Bcl‐2/Bax ratio, but siNrf2 reduced the ability of Res to promote apoptosis. We conclude that Res inhibits ROS production by activating the Nrf2 pathway, thereby inhibiting activation of NF‐κB and proliferation and migration of RA‐FLSs, to induce apoptosis. Targeting the Nrf2–Keap1 pathway may be a relevant aim of using Res in the treatment of RA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

Zhang

Wang

et al. 2019

Annals of the New York Academy of Sciences

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“…Jazzara et al [170] concluded that λ-carrageenan (sulfated galactans found in certain red seaweeds) could be a promising bioactive polymer, showed a remarkable inhibitory effect on MDA-MB-231(triple negative breast cancer cell line) cell migration [171]. Several studies support polyphenols [172][173][174][175][176], flavonoids [177][178][179][180][181][182][183][184][185][186], fucoidan [159,160,166,[187][188][189][190][191][192][193][194][195], lutein/zeaxanthin [196][197][198][199][200], other seaweed alkaloids, peptides, tannins and polysaccharides [132,164,[201][202][203][204][205][206][207][208][209][210] in breast cancer management. The number of deaths from colorectal cancer in Japan continues to increase [211], it is the third most common diagnosis and second deadliest malignancy for both sexes combined…”

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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“…Jazzara, et al [380] concluded that λ-carrageenan ( Figure 6f) (sulfated galactans found in certain red seaweeds) could be a promising bioactive polymer, showed a remarkable inhibitory effect on MDA-MB-231(triple negative breast cancer cell line) cell migration [381]. Several studies support polyphenols [382][383][384][385][386], flavonoids [387][388][389][390][391][392][393][394][395], fucoidan [396][397][398][399][400][401][402][403][404][405][406][407], lutein/zeaxanthin [408][409][410][411][412], other seaweed alkaloids, peptides, tannins and polysaccharides [413][414][415][416][417][418][419][420][421][422][423][424][425] in breast cancer management ( Figure 7).…”

Section: Camptotheca Acuminate (Xǐ Shù or Happy Tree) Leavesmentioning

confidence: 99%

Alternative Treatments for Cancer Prevention and Cure [Part 1]

Mohiuddin¹

2019

APCT

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Many lay people along with some so called "key opinion leaders" have a common slogan "There's no answer for cancer". Again, mistake delays proper treatment and make situation worse, more often. Compliance is crucial to obtain optimal health outcomes, such as cure or improvement in QoL. Patients may delay treatment or fail to seek care because of high out-of-pocket expenditures. Despite phenomenal development, conventional therapy falls short in cancer management. There are two major hurdles in anticancer drug development: dose-limiting toxic side effects that reduce either drug effectiveness or the QoL of patients and complicated drug development processes that are costly and time consuming. Cancer patients are increasingly seeking out alternative medicine and might be reluctant to disclose its use to their oncology treatment physicians. But there is limited available information on patterns of utilization and efficacy of alternative medicine for patients with cancer. As adjuvant therapy, many traditional medicines shown efficacy against brain, head and neck, skin, breast, liver, pancreas, kidney, bladder, prostate, colon and blood cancers. The literature reviews non-pharmacological interventions used against cancer, published trials, systematic reviews and meta-analyses.

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NrF2/ARE and NF-κB Pathway Regulation May be the Mechanism for Lutein Inhibition of Human Breast Cancer Cell

Abstract: The effect of lutein antiproliferation was mediated by activation of the NrF2/ARE pathway, and blocking of the NF-κB signaling pathway.

Cited by 48 publications

References 29 publications

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

Seaweeds: An Extensive Review of Medicinal Values

Alternative Treatments for Cancer Prevention and Cure [Part 1]

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