Nrf2 activation and down-regulation of HMGB1 and MyD88 expression by amnion membrane extracts in response to the hypoxia-induced injury in cardiac H9c2 cells

Faridvand, Yousef; Nozari, Samira; Vahedian, Vahid; Safaie, Naser; Pezeshkian, Masoud; Haddadi, Parinaz; Mamipour, Mina; Rezaie-nezhad, Arezoo; Jodati, Ahmadreza; Nouri, Mohammad

doi:10.1016/j.biopha.2018.10.035

Cited by 22 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GR may also upregulate the Nrf2 pathway by inhibiting HMGB1 and is involved in antioxidant effects. The Nrf2-induced expression of HO-1 also inhibits the expression of HMGB1, thereby reducing the incidence of inflammation (39,40). Such Nrf2-HO-1-HMGB1 feedback loops may be mechanisms involved in the effects of GR.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizin protects human melanocytes from H2O2‑induced oxidative damage via the Nrf2‑dependent induction of HO‑1

et al. 2019

View full text Add to dashboard Cite

Oxidative stress serves a critical role in melanocyte death and is considered to be a major cause of vitiligo. The nuclear factor E2-related factor 2 (Nrf2) signaling pathway has an important role in the antioxidative stress mechanisms of melanocytes. Glycyrrhizin (GR) is a derivative of herbal medicines used to treat hepatitis and allergic disease due to its antiviral and anti-allergy effects. GR also activates Nrf2 and induces the expression of heme oxygenase (HO)-1 in macrophages. Whether GR can protect human melanocytes from oxidative stress remains unknown. The present study investigated the potential protective effects of GR against oxidative stress in human melanocytes and the mechanisms involved. Following exposure to 0.5 mM hydrogen peroxide (H 2 O 2 ), human primary melanocytes were treated with 1 mM GR. Cell viability was determined using a Cell Counting Kit-8 assay, and apoptosis was evaluated by flow cytometry. GR treatment significantly improved cell viability, reduced the apoptotic rate of melanocytes and reduced the level of reactive oxygen species in human melanocytes. Furthermore, GR induced the nuclear translocation of Nrf2 and induced the expression of HO-1 in melanocytes. The knockdown of Nrf2 by small interfering RNA or the inhibition of HO-1 by ZnPP reversed the protective effect of GR on melanocytes against H 2 O 2 -induced cytotoxicity and apoptosis. These data demonstrate that GR protects human melanocytes from H 2 O 2 -induced oxidative damage via the Nrf2-dependent induction of HO-1, providing evidence for the application of GR in the treatment of vitiligo.

show abstract

Section: Discussionmentioning

confidence: 99%

Glycyrrhizin protects human melanocytes from H2O2‑induced oxidative damage via the Nrf2‑dependent induction of HO‑1

et al. 2019

View full text Add to dashboard Cite

show abstract

“…HMGB1 is a key inflammatory cytokine involved in kidney diseases, and Nrf2 is considered a master regulator of cellular redox signaling, inflammatory pathway. Inhibition of the inflammatory mediator HMGB1 along with upregulation of Nrf2/HO-1 has been demonstrated to significantly improve hypoxia-induced cell injury [41,42]. Another study also shows that increased Nrf2 activity can attenuate hyperoxiainduced inflammatory by inhibiting the accumulation of extracellular HMGB1 [43].…”

Section: Keap1mentioning

confidence: 96%

Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway

Zhao

Feng

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Contrast-induced acute kidney injury (CI-AKI) is the third common cause of acute kidney injury (AKI), which is associated with poor short- and long-term outcomes. Currently, effective therapy strategy for CI-AKI remains lacking. Stanniocalcin-1 (STC1) is a conserved glycoprotein with antiapoptosis and anti-inflammatory functions, but the role of STC1 in controlling CI-AKI is unknown. Here, we demonstrated a protective role of STC1 in contrast-induced injury in cultured renal tubular epithelial cells and CI-AKI rat models. Recombinant human STC1 (rhSTC1) regulated mitochondrial quality control, thus suppressing contrast-induced mitochondrial damage, oxidative stress, inflammatory response, and apoptotic injury. Mechanistically, activation of the Nrf2 signaling pathway contributes critically to the renoprotective effect of STC1. Together, this study demonstrates a novel role of STC1 in preventing CI-AKI and reveals Nrf2 as a molecular target of STC1. Therefore, this study provides a promising preventive target for the treatment of CI-AKI.

show abstract

“…This procedure caused nuclear factor erythroid‐2‐related factor 2 (Nrf2) a heme‐oxygenase 1 (HO‐1) expression upregulation with concomitant downregulation of inflammatory cascade‐related proteins levels. It gives hope for a new strategy to prevent hypoxia‐associated myocardial dysfunction …”

Section: New and Unusual Applications Of Amniotic Membrane In The Woumentioning

confidence: 99%

“…It gives hope for a new strategy to prevent hypoxia-associated myocardial dysfunction. 110 Another unusual application of amnion is its use in vascular reconstructions, for example as a substitute in the external jugular vein. The experiment was performed on juvenile sheep-the amniotic membrane was rolled around the tube and such conduits were interposed to the external jugular vein.…”

Section: New and Unusual Applications Of Amniotic Membrane In The Wmentioning

confidence: 99%

Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases ‐ Stevens‐Johnson syndrome and toxic epidermal necrolysis treatment

Klama-Baryła¹,

Rojczyk

Kitala³

et al. 2020

International Wound Journal

View full text Add to dashboard Cite

Unique properties of amniotic membrane make it a promising source for tissue engineering and a clinically useful alternative for patients suffering from chronic wounds including, for example, ulcers, burns, ocular surface damages and wounds occurring in the course of bullous diseases like stevens‐johnson syndrome and toxic epidermal necrolysis. Its use has many advantages over standard wound care, as it contains pluripotent cells, nutrients, anti‐fibrotic and anti‐inflammatory cytokines, growth factors and extracellular matrix (ECM) proteins. Placental tissues can be prepared as a medical component, an advanced therapy medicinal product or a tissue graft. In addition to basic preparation procedures such as washing, rinsing, cutting, drying and sterilisation, there are many optional steps such as perforation, crosslinking and decellularisation. Finally, transplants should be properly stored—in cryopreserved or dehydrated form. In recent years, many studies including basic science and clinical trials have proven the potential to expand the use of amniotic membrane and amnion‐derived cells to the fields of orthopaedics, dentistry, surgery, urology, vascular tissue engineering and even oncology. In this review, we discuss the role of placental tissues in skin wound healing and in the treatment of various diseases, with particular emphasis on bullous diseases. We also describe some patented procedures for placental tissue grafts preparation.

show abstract

Nrf2 activation and down-regulation of HMGB1 and MyD88 expression by amnion membrane extracts in response to the hypoxia-induced injury in cardiac H9c2 cells

Cited by 22 publications

References 39 publications

Glycyrrhizin protects human melanocytes from H2O2‑induced oxidative damage via the Nrf2‑dependent induction of HO‑1

Glycyrrhizin protects human melanocytes from H2O2‑induced oxidative damage via the Nrf2‑dependent induction of HO‑1

Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway

Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases ‐ Stevens‐Johnson syndrome and toxic epidermal necrolysis treatment

Contact Info

Product

Resources

About