NREM Sleep and Antiepileptic Medications Modulate Epileptiform Activity by Altering Cortical Synchrony

Nayak, Chetan S.; Mariyappa, N.; Majumdar, Kaushik; Ravi, G.; Prasad, Pradeep D.; Nagappa, Madhu; Thennarasu, Kandavel; Taly, Arun B.; Sinha, Sanjib

doi:10.1177/1550059417747436

Cited by 9 publications

(13 citation statements)

References 26 publications

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“…Moreover, it should be noted that due to the limited number of IEDs, the authors could not determine the effect of AEDs on cortical synchronization in the case of the focal epilepsy under study. However, the study emphasizes that the sleep phase has an impact on the level of synchronization preceding IEDs, and on the basis of studies on juvenile myoclonic epilepsy, they confirm that AEDs, by causing wave desynchronization, delay the appearance of IEDs [31].…”

Section: Brief Description Of the State Of Knowledgementioning

confidence: 61%

“…In the study by Nayak et al [31], the highest synchronization and number of IEDs in the N1 phase were recorded. Nayak et al [36] exclude IEDs from their research and indicate an increased synchronization of the delta and theta bands, not only in TLE, but also in other types of epilepsy.…”

Section: Characteristic Dischargesmentioning

confidence: 99%

“…Characteristic discharges. Research by Del Felice et al [30], Nayak et al [31], Giorgi et al [32] focuses on the analysis of interictal epileptiform discharges (IEDs). This characteristic brain activity, which differs from that during an epileptic seizure, is due to different mechanisms activated by specific ligands [33].…”

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

“…The authors wanted to confirm the hypothesis that morning sleep (after deprivation), which is characterized by greater instability, may cause an increased frequency of IEDs [32]. Nayak et al [31] focused on the NREM phase in propagating IEDs by assessing these waves during sleep and wakefulness. It should be noted that the studies also took into account the effects of AEDs.…”

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

“…To investigate the NREM phase and the effect of antiepileptic drugs (sodium valproate and carbamazepine) on epilepsy markers Nayak et al [31] used the timing phase assessment preceding the IEDs. 120 people participated in the study, divided into 3 groups of 40 people each, according to the type of epilepsy.…”

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

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Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

Drabik¹,

Sarnacki²,

Miziak³

2021

Med Og Nauk Zdr.

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Introduction. The analysis of sleep and its phases in the context of various pathophysiologies has attracted increasing attention from the scientific community; therfore, this review of the literature focuses on temporal lobe epilepsy (TLE). Objective. The aim of the review is to systematize and update the knowledge and research currently available on the interplay of sleep deprivation and seizures in TLE, with a focus on MTLE. Materials and method. The following keyword combinations were used to search the Pubmed, Science Direct and Google Scholar databases: sleep disturbance in mesial temporal lobe epilepsy, sleep in temporal lobe epilepsy, nocturnal temporal lobe epilepsy, temporal epilepsy sleep disturbance. After applying exclusion criteria, 23 papers were selected for the review. Brief description of the state of knowledge. The publications qualified for the review were divided into 7 categories in terms of the subject of the publication. These categories relate to characteristic brain waves, memory and its consolidation processes, heart and sleep apnea, anti-epileptic drugs, motor disorders and lateralization of the discharges. Articles that did not fit into any of the previously mentioned categories were placed in the 'Other' group. Conclusions. It is agreed that sleep is an important factor that should be taken into account when selecting the appropriate treatment and researching new AEDs. Moreover, sleep is significant to the patient›s quality of life, has a profound impact on its components, for example, physical and social functions, emotions and leisure, but may also influence the effectiveness of therapy.

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Section: Brief Description Of the State Of Knowledgementioning

confidence: 61%

Section: Characteristic Dischargesmentioning

confidence: 99%

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

See 3 more Smart Citations

Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

Drabik¹,

Sarnacki²,

Miziak³

2021

Med Og Nauk Zdr.

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Chronotype and sleep disorders in children with epilepsy

Özçelik

Karadağ

2023

Epileptic Disorders

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The circadian rhythm can affect the frequency and resistance of epileptic seizures. In this cross-sectional study, we examined the impact of chronobiology and sleep disturbances on children with epilepsy. Methods: One hundred and twenty-five children and adolescents (55 patients and 70 controls) were included in the study. All participants were asked to complete the Revised Child Anxiety and Depression Scale-Child Version (RCADS-CV), Sleep Disturbances Scale for Children (SDSC), Childhood Chronotype Questionnaire (CCQ).Results: According to the CCQ results, controls had longer sleep duration (median 595 vs. 570), lower morningness-eveningness scores (median: 28 vs. 30), and higher rates of the morningness (12.9% vs. 1.8%) and intermediate (74.3% vs. 60%) chronotypes. The children and adolescents with epilepsy scored significantly higher in the Sleep breathing disorders (p = .001), Disorders of arousal nightmares (p = .044), Sleep-wake transition disorders (p = .037), Disorders of excessive somnolence (p = .001), and total SDCS (p = .046) scores. According to the RCADS-CV results, the children with epilepsy scored significantly higher in all subscales in comparison to controls (p < .05).

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Non-lesional Bilateral Mesial Temporal Lobe Epilpesy

Quraishi,

Herlopian

2024

Epilepsy Surgery: A Practical Case-Based Approach

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NREM Sleep and Antiepileptic Medications Modulate Epileptiform Activity by Altering Cortical Synchrony

Cited by 9 publications

References 26 publications

Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

Chronotype and sleep disorders in children with epilepsy

Non-lesional Bilateral Mesial Temporal Lobe Epilpesy

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