NR5A2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting MMP25 transcription
wang xiao,
Guang Chen,
Weimin Shan
et al.
Abstract:Epithelial-to-mesenchymal transition (EMT) is crucial for the progression of renal tubulointerstitial fibrosis, typically leading to end-stage renal failure. The role of Nuclear receptor subfamily 5 group A member 2 (NR5A2) in renal fibrosis is not yet fully understood. This research assessed NR5A2 expression in human renal fibrosis and in mouse models with unilateral ureteral obstruction (UUO). We further investigated NR5A2's function in TGF-β1-driven renal tubular EMT. Our findings demonstrated a significant… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.