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Abstract

Non Poliovirus enteroviruses (NPEV) are infectious agents which can determine various infections. They are more and more isolated within the context of the surveillance of acute flaccid paralysis (AFP) and raise a problem of antigenic identification. In Côte d'Ivoire the serotypes of NPEV circulating are unknown. In order to determine the epidemiological and virology characteristics of human (NPEV) stemming from virology investigations from 1996 to 2004, enteroviruses strains isolated from stools and from cerebrospinal fluid have been analysed. The biological products have been tested according to the procedures recommended by the World Health Organisation (WHO) within the context of the virology surveillance of acute flaccid paralysis and the antigenic identification by seroneutralization and serotyping has been done. Out of 144 isolates obtained from 10187 specimens, 637 were Poliovirus strains and 807 NPEV strains (7.9%). Among them 16.3% have been isolated during carrier studies and 83.7% were associated with cases of AFFP Out of the 807 strains of NPE, 218 strains have been tested by serotyping and the serotype of 77 strains (35.32%) has been determined: Coxsackievirus B (41.6%) and different serotypes of Echovirus (58.4%). The proportion of untypable strains (62.3%) confirms the difficulties to identify NPEV with the conventional available reagents. The molecular diagnosis is becoming necessary in order to establish a list of the serotypes of NPEV circulating and associated with clinical features in the country