“…Results of recent studies showed 1,1-bis(3′-indolyl)-1-(3,5-disubstituted-4-hydroxyphenyl) methane (DIM8-3,5) and 1,1-bis(3′-indolyl)-1-(3,5-disubstituted phenyl) methane (DIM-3,5) compounds were NR4A1 ligands that were potent inhibitors of tumor growth in orthotopic mouse xenograft model [ 34 , 35 ]. The following compounds ( Figure 1 ) were synthesized for this study: DIM8-3,5 compounds: DIM8-3,5-Cl2, DIM8-3,5-Br 2 , DIM8-3,5-(Bu) 2 , DIM8-3,5-(CH3) 2 , DIM8-3,5-(OCH 3 ) 2 , DIM8-3-Cl-5-F, DIM8-3-Br-5-OCH 3 , and DIM8-3-Cl-5-OCH 3 ; and DIM-3,5-compounds: DIM-3,5-Cl 2 , DIM-3,5-Br 2 , DIM-3,5-F 2 , DIM-3,5-(CH 3 ) 2 , DIM-3,5-(OCH 3 ) 2 , DIM-3-Br-5-CF 3 , DIM-3-CF-5-CF 3 , DIM-3-F-5-CF 3 , DIM-3-Cl-5-OCF 3 , DIM-3-Br-5-OCF 3 , DIM-3-Br-5-OCH 3 , and DIM-3-Cl-5-OCF 3 .…”