NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer

Yousefi, Hassan; Fong, Jordyn T

doi:10.3389/fonc.2022.777824

Cited by 7 publications

(3 citation statements)

References 47 publications

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“…Nr4a is a group of transcription factors that play crucial roles in various physiological processes [65]. Nr4a members include three related proteins: Nr4a1 (Nur77 or TR3), Nr4a2 (Nurr1), and Nr4a3 (Nor-1).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing

Al-Shalan,

Hu,

Wang

et al. 2023

Viruses

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Influenza A virus (IAV) is known to cause mild to severe respiratory illness. Under some conditions, the infection can lead to pneumonia (viral or bacterial), acute respiratory distress syndrome, and other complications that can be fatal, especially in vulnerable populations such as the elderly, young children, and individuals with underlying health conditions. Despite previous studies, little is known about the host immune response and neuroimmune interactions in IAV infection. Using RNA sequencing, we performed transcriptomic analysis of murine lung tissue 21 days post infection (dpi) with IAV (H1N1) in order to find the differentially expression genes (DEGs) related to the host immune response and neuroimmune interactions inside the lung during recovery. Among 792 DEGs, 434 genes were up-regulated, whereas 358 genes were down-regulated. The most prominent molecular functions of the up-regulated genes were related to the immune response and tissue repair, whereas a large proportion of the down-regulated genes were associated with neural functions. Although further molecular/functional studies need to be performed for these DEGs, our results facilitate the understanding of the host response (from innate immunity to adaptive immunity) and neuroimmune interactions in infected lungs at the recovery stage of IAV infection. These genes might have potential uses as mechanistic/diagnostic biomarkers and represent possible targets for anti-IAV therapies.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing

Al-Shalan,

Hu,

Wang

et al. 2023

Viruses

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“…Mutations in HOX genes cause alterations in transcription factors and processing of genetic information [37,38]. The mutations in the NR4 (nuclear receptor 4) family can be present in meningiomas, and these genes regulate the signalling pathways involved in apoptosis, migration, and proliferation [39,40]. FOSL2, which is implicated in the regulation of cell differentiation, proliferation, and transformation, can also be mutated in certain meningiomas.…”

Section: Meningiomamentioning

confidence: 99%

Modelling Meningioma Using Organoids: A Review of Methodologies and Applications

López Vásquez,

Gray,

Henry

et al. 2023

Organoids

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Meningiomas are the most common tumours of the central nervous system. According to the World Health Organization (WHO), this disease is classified into three different grades: 80% of meningioma patients present with benign grade I tumours, while less than 2% present with malignant grade III meningiomas. Despite affecting thousands of people worldwide, much remains unknown about this disease, and the development of systemic treatments is still far behind in comparison to other types of tumours. Therefore, forming 3D structures (spheroids and organoids) could facilitate research on the mechanisms of formation, proliferation, migration, and invasion of these, for the most part, benign tumours, while also helping in the process of drug development. To date, there are three published methods for the formation of meningioma organoids primarily derived from patient tissue samples. Organoids offer many advantages in the development of treatments because they recapitulate the cellular complexity within tumours. These new methodological advances could open a substantial number of possibilities for the further characterisation and treatment of meningiomas. This review includes an overview of the disease and a description and comparison of established protocols for meningioma organoid formation.

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“…Recent reports suggest that the NR4A family receptors may bind to unsaturated fatty acids in the LBD to exhibit regulation of metabolism ( 13 ). For example, in breast cancer, NR4A1-NR4A3 regulates glycolysis to participate in cell progression ( 14 ). The NR4A receptors are also associated with the activation of T cell, which involving in cancer immunotherapy ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of NR4A1 in cancer: Focus on metabolism

et al. 2022

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Metabolic reprogramming is a vital hallmark of cancer, and it provides the necessary energy and biological materials to support the continuous proliferation and survival of tumor cells. NR4A1 is belonging to nuclear subfamily 4 (NR4A) receptors. NR4A1 plays diverse roles in many tumors, including melanoma, colorectal cancer, breast cancer, and hepatocellular cancer, to regulate cell growth, apoptosis, metastasis. Recent reports shown that NR4A1 exhibits unique metabolic regulating effects in cancers. This receptor was first found to mediate glycolysis via key enzymes glucose transporters (GLUTs), hexokinase 2 (HK2), fructose phosphate kinase (PFK), and pyruvate kinase (PK). Then its functions extended to fatty acid synthesis by modulating CD36, fatty acid-binding proteins (FABPs), sterol regulatory element-binding protein 1 (SREBP1), glutamine by Myc, mammalian target of rapamycin (mTOR), and hypoxia-inducible factors alpha (HIF-1α), respectively. In addition, NR4A1 is involving in amino acid metabolism and tumor immunity by metabolic processes. More and more NR4A1 ligands are found to participate in tumor metabolic reprogramming, suggesting that regulating NR4A1 by novel ligands is a promising approach to alter metabolism signaling pathways in cancer therapy. Basic on this, this review highlighted the diverse metabolic roles of NR4A1 in cancers, which provides vital references for the clinical application.

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NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer

Cited by 7 publications

References 47 publications

Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing

Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing

Modelling Meningioma Using Organoids: A Review of Methodologies and Applications

Therapeutic potential of NR4A1 in cancer: Focus on metabolism

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