NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors
Kensuke Nakagawara,
Makoto Ando,
Tanakorn Srirat
et al.
Abstract:BackgroundAntitumor effect of chimeric antigen receptor (CAR)-T cells against solid tumors is limited due to various factors, such as low infiltration rate, poor expansion capacity, and exhaustion of T cells within the tumor. NR4A transcription factors have been shown to play important roles in T-cell exhaustion in mice. However, the precise contribution of each NR4a factor to human T-cell differentiation remains to be clarified.MethodsIn this study, we deleted NR4A family factors,NR4A1,NR4A2, and NR4A3,in hum… Show more
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