NR2F2 is required in the embryonic testis for Fetal Leydig Cell development
Aitana Perea-Gomez,
Natividad Bellido-Carreras,
Magali Dhellemmes
et al.
Abstract:Male genital development in XY mammalian fetuses is triggered by the action of hormones, including testosterone, secreted by the developing testes. Defects in this process are a cause for Differences in Sex Development (DSD), one of the most common congenital abnormalities in humans. Fetal Leydig Cells (FLC) play a central role for the synthesis of masculinizing hormones in the developing testes. Yet, the genetic cascade controlling their differentiation is poorly understood. Here we investigate the role of th… Show more
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