NR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis, and Warburg effects of cervical cancer through interacting with IGF2BP3

Ren, Ailing; Gong, Feilong; Liu, Guokun; Wang, Fan

doi:10.1007/s11010-023-04692-5

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…Originally, it is known that tumor cells preferentially consume large amounts of glucose relative to most non-transformed cells through increased glycolysis, a phenomenon described as the “Warburg effect”. This provides tumor cells with a mitochondria-independent metabolic program that allows them to quickly produce energy to sustain increased rates of proliferation and malignant progression [ 2 , 3 , 4 ]. In the Warburg effect, glycolysis terminates with L-lactate production and secretion despite the presence of oxygen.…”

Section: Introduction: Autophagy a Key Degradation Program For Nutrie...mentioning

confidence: 99%

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

Ghahari,

Telittchenko,

Loucif

et al. 2023

IJMS

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Like other chronic viral infections, HIV-1 persistence inhibits the development of antigen-specific memory T-cells, resulting in the exhaustion of the immune response and chronic inflammation. Autophagy is a major lysosome-dependent mechanism of intracellular large-target degradation such as lipid and protein aggregates, damaged organelles, and intracellular pathogens. Although it is known that autophagy may target HIV-1 for elimination, knowledge of its function as a metabolic contributor in such viral infection is only in its infancy. Recent data show that elite controllers (EC), who are HIV-1-infected subjects with natural and long-term antigen (Ag)-specific T-cell protection against the virus, are characterized by distinct metabolic autophagy-dependent features in their T-cells compared to other people living with HIV-1 (PLWH). Despite durable viral control with antiretroviral therapy (ART), HIV-1-specific immune dysfunction does not normalize in non-controller PLWH. Therefore, the hypothesis of inducing autophagy to strengthen their Ag-specific T-cell immunity against HIV-1 starts to be an enticing concept. The aim of this review is to critically analyze promises and potential limitations of pharmacological and dietary interventions to activate autophagy in an attempt to rescue Ag-specific T-cell protection among PLWH.

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Section: Introduction: Autophagy a Key Degradation Program For Nutrie...mentioning

confidence: 99%

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

Ghahari,

Telittchenko,

Loucif

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

NR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis, and Warburg effects of cervical cancer through interacting with IGF2BP3

Cited by 1 publication

References 41 publications

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

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