NPY gene polymorphism in vitiligo: A case–control study in Egyptian patients

Bakry, Ola Ahmed; Mariee, Alaa; Badr, Iman; Tayel, Nermin; Gendy, Samar El

doi:10.4103/ijd.ijd_104_18

Cited by 5 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NPY, a 36 amino acid neuromodulator secreted by neurons, is believed to be involved in control of vitiligo development ( 7 , 21 , 38 , 39 ). Several studies have shown that the NPY levels of lesions and plasma in patients with vitiligo are significantly higher than in healthy volunteers ( 7 , 21 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that the NPY levels of lesions and plasma in patients with vitiligo are significantly higher than in healthy volunteers ( 7 , 21 , 38 ). Furthermore, NPY −399T/C (rs16147) and +1128T/C (rs16139) polymorphisms are correlated with vitiligo susceptibility and increase NPY transcription activity ( 39 , 40 ). In this study, we found that camouflage combined with psychotherapy could considerably decrease serum NPY level.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Chang

Zhang

et al. 2022

Front. Med.

View full text Add to dashboard Cite

Background and ObjectivesThe efficacy of camouflage combined with psychotherapy and the underlying mechanisms are poorly understood in vitiligo management. This study aimed to investigate the joint efficacy and further explore psycho-neuro-endocrine-immune-skin interactions.Patients and MethodsIn a prospective, non-randomized and concurrent controlled trial, patients were divided into two groups. Quality of life (QOL) was evaluated using the Chinese version of the Vitiligo Life Quality Index (VLQI-C). Serum levels of neuropeptides and cytokines were detected by enzyme-linked immunosorbent assay.ResultsA total of 149 patients were included for final evaluation. After treatment for 4 weeks, total and subcategory quality of life scores in the intervention group were much lower than in the control group. Serum levels of neuropeptide-Y (NPY) and melanin-concentrating hormone (MCH) significantly decreased, and serum level of adrenocorticotropic hormone (ACTH) increased in both active and stable patients of the intervention group, but not in the control group. In addition, the serum levels of interferon-γ (IFN-γ), CXC chemokine ligand 10 (CXCL10), and interleukin-1β (IL-1β) decreased in both the active and stable patients of the intervention group and only in the active patients of the control group.ConclusionsThe combination of camouflage and psychotherapy provided a clinically meaningful improvement in quality of life and ameliorated the outcome by likely modulating the psycho-neuro-endocrine-immuno-skin system during vitiligo management.Clinical Trial Registrationwww.clinicaltrials.gov/ct2/show/NCT03540966, identifier: NCT03540966.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Chang

Zhang

et al. 2022

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Skin neuroendocrinology literature has long suggested the involvement of NPY in skin pathology [47]. In support of this hypothesis, clinical studies have shown that genetic mutations in NPY are associated with increased susceptibility for vitiligo [48][49]. Studies have also shown that NPY is more highly expressed in the circulation and affected skin from patients suffering from atopic dermatitis and vitiligo [20][21][22][23][24][25]27].…”

Section: Discussionmentioning

confidence: 99%

Chronic overexpression of neuropeptide Y in the skin is sufficient to induce inflammation and epidermal and dermal pathology

Anderson

Palmer

Słomiński

et al. 2021

Preprint

View full text Add to dashboard Cite

Neuropeptide Y (NPY) is a pleiotropic peptide produced in the central nervous system and peripheral organs. Despite conjectures that NPY may have a role in skin physiology and pathology, the effects of NPY in this organ remain poorly understood. We reported that a knock-in mouse with entopic NPY overexpression exhibits significantly elevated NPY in the skin, accompanied by premature and progressive hair graying secondary to depletion of melanocyte stem cells within hair follicles. However, the question remains as to whether NPY overexpression in the skin can induce non-melanocyte pathology. In this study, we employed this mouse to investigate the consequences of skin-specific overexpression of NPY. Our findings show that chronic NPY overexpression in the skin induces dermal fibrosis and epidermal hyperkeratosis. Additionally, NPY overexpression induces significant accumulation of macrophages and regulatory T cells in the dermis. RNA sequencing of whole skin from NPY-overexpressing mice further reveals NPY-mediated transcriptional changes consistent with inflammatory processes and inflammation-associated skin changes and highlights novel cell types involved in the NPY-mediated response in the skin. Together, these results provide long-awaited evidence of NPY’s involvement in skin pathology, providing a background for defining the precise role of NPY in the regulation of cutaneous homeostasis and disease.

show abstract

“…In this case, the TC haplotype (+1128 T/-399 C) is associated with a 2.3-fold greater odds for developing vitiligo. Similarly, in an Egyptian population, the C/C and T/C genotypes of the -399T/C SNP are associated with a 3.75- and 4.6-fold increased odds for disease ( 103 ). Both the -399 and +1128 SNPs also appear to have functional consequences on NPY gene regulation.…”

Section: Genetic Associations Of Npy With Skin Pathologymentioning

confidence: 97%

Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology

et al. 2022

View full text Add to dashboard Cite

Neuropeptide Y is widely distributed within the body and has long been implicated as a contributor to skin disease based on the correlative clinical data. However, until recently, there have been few empirical investigations to determine whether NPY has a pathophysiological role in the skin. Due to appearance-altering phenotypes of atopic dermatitis, psoriasis, and vitiligo, those suffering from these diseases often face multiple forms of negative social attention. This often results in psychological stress, which has been shown to exacerbate inflammatory skin diseases – creating a vicious cycle that perpetuates disease. This has been shown to drive severe depression, which has resulted in suicidal ideation being a comorbidity of these diseases. Herein, we review what is currently known about the associations of NPY with skin diseases and stress. We also review and provide educated guessing what the effects NPY can have in the skin. Inflammatory skin diseases can affect physical appearance to have significant, negative impacts on quality of life. No cure exists for these conditions, highlighting the need for identification of novel proteins/neuropetides, like NPY, that can be targeted therapeutically. This review sets the stage for future investigations into the role of NPY in skin biology and pathology to stimulate research on therapeutic targeting NPY signaling in order to combat inflammatory skin diseases.

show abstract

NPY gene polymorphism in vitiligo: A case–control study in Egyptian patients

Cited by 5 publications

References 10 publications

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Chronic overexpression of neuropeptide Y in the skin is sufficient to induce inflammation and epidermal and dermal pathology

Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology

Contact Info

Product

Resources

About