NPM1 Quantitative Monitoring of Minimal Residual Disease in Acute Myeloid Leukemia Allows More Precise Selection of Patients for Allogeneic Stem Cell Transplantation without Affecting Their Survival
Abstract:Introduction: Mutations of the NPM1 gene (NPM1mut) are considered a favorable prognostic marker in acute myeloid leukemia (AML). Data from a prospective randomized trial have shown that in young AML patients with NPM1mut upfront allogeneic stem cell transplantation (allo-SCT) performed in first complete remission (CR1) may lead to a significantly improved overall survival (OS) (Dohner K, Blood 2005). However, due to considerable allo-SCT-associated morbidity and mortality and a relatively favorable outcome of … Show more
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